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关于此项目
经验公式（希尔记法）:
C65H124Na2O17P2
化学文摘社编号:
分子量:
1285.60
MDL number:
NACRES:
NA.25
UNSPSC Code:
51191904
产品名称
14:0 Cardiolipin (sodium salt), Avanti Research™ - A Croda Brand
description
1′,3′-bis[1,2-dimyristoyl-sn-glycero-3-phospho]-glycerol (sodium salt), chloroform
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
10 mg/mL (750332C-25mg), 25 mg/mL (750332C-200mg)
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
assay
>99% (TLC)
form
solution
packaging
pkg of 1 × 2.5 mL (750332C-25mg), pkg of 2 × 4 mL (750332C-200mg)
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General description
Cardiolipin, the mitochondrial-specific phospholipid, helps maintain mitochondrial function, membrane potential and structural support for the inner mitochondrial membrane and the proteins in it. Concentration and composition changes of cardiolipin have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy (Barth syndrome). Cardiolipin has also been shown as a signaling molecule in apoptosis.
Application
14:0 Cardiolipin (sodium salt) has been used for the mass spectrometry (MS) analysis to determine the structure of lipid A.
Packaging
5 mL Clear Glass Sealed Ampule (750332C-200mg)
5 mL Clear Glass Sealed Ampule (750332C-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system, Liver,Kidney
wgk
WGK 3
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
易制毒化学品（2类）
危险化学品
此项目有
Rapid lipid a structure determination via surface acoustic wave nebulization and hierarchical tandem mass spectrometry algorithm
Yoon SH, et al.
Rapid Communications in Mass Spectrometry, 30(23), 2555-2560 (2016)
Role of cardiolipin alterations in mitochondrial dysfunction and disease
Chicco AJ and Sparagna GC
American Journal of Physiology. Cell Physiology, 292(1), C33-C44 (2007)
Vladimir B Ritov et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 831(1-2), 63-71 (2005-12-13)
Cardiolipin is a phospholipid that is specific to the inner mitochondrial membrane and essential for numerous mitochondrial functions. Accordingly, a quantitative assay for cardiolipin can be a valuable aspect of assessing mitochondrial content and functional capacity. The current study was
Erum Malik et al.
Biochimica et biophysica acta. Biomembranes, 1862(2), 183141-183141 (2019-12-04)
Linearized esculentin 2 EM (E2EM-lin) from the frog, Glandirana emeljanovi was highly active against Gram-positive bacteria (minimum lethal concentration ≤ 5.0 μM) and strongly α-helical in the presence of lipid mimics of their membranes (>55.0%). The N-terminal α-helical structure adopted by E2EM-lin showed
Paulina Perczyk et al.
Biochimica et biophysica acta. Biomembranes, 1862(6), 183239-183239 (2020-03-03)
Soil bacteria are decomposer organisms crucial for the biodegradation of organic pollutants, mineralization of dead organic matter and the turnover of biogenic elements. In their environment they are constantly exposed to membrane-lytic enzymes emitted to the soil by other microorganisms
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