Merck
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780200C

Avanti

16:0 PE MCC

1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt), chloroform

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别名:
1,2-二十六酰基-sn-甘油-3-磷酸乙醇胺-N-[4-(对马来酰亚胺基甲基)环己烷-羧酰胺](钠盐)
Empirical Formula (Hill Notation):
C49H86N2O11PNa
分子量:
933.18
NACRES:
NA.25

检测方案

>99% (TLC)

形式

liquid

包装

pkg of 1 × 2.5 mL (780200C-25mg)

manufacturer/tradename

Avanti Polar Lipids 780200C

浓度

10 mg/mL (780200C-25mg)

application(s)

advanced drug delivery

运输

dry ice

储存温度

−20°C

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此商品
780200P780201C780201P
16:0 PE MCC 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt), chloroform

Avanti

780200C

16:0 PE MCC

16:0 PE MCC 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt), powder

Avanti

780200P

16:0 PE MCC

18:1 PE MCC 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt), chloroform

Avanti

780201C

18:1 PE MCC

18:1 PE MCC 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt), powder

Avanti

780201P

18:1 PE MCC

form

liquid

form

powder

form

liquid

form

powder

packaging

pkg of 1 × 2.5 mL (780200C-25mg)

packaging

pkg of 1 × 25 mg (780200P-25mg)

packaging

pkg of 1 × 2.5 mL (780201C-25mg)

packaging

pkg of 1 × 100 mg (780201P-100mg), pkg of 1 × 25 mg (780201P-25mg)

manufacturer/tradename

Avanti Polar Lipids 780200C

manufacturer/tradename

Avanti Polar Lipids 780200P

manufacturer/tradename

Avanti Polar Lipids 780201C

manufacturer/tradename

Avanti Polar Lipids 780201P

concentration

10 mg/mL (780200C-25mg)

concentration

-

concentration

10 mg/mL (780201C-25mg)

concentration

-

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

一般描述

1,2-二棕榈酰基-sn-甘油-3-磷酸乙醇胺-N-[4-(马来酰亚胺基甲基)环己烷-羧酰胺](16:0 PE MCC)是一种脂质,其脂质包含通过其磷酸基团与两个棕榈酸连接的磷酸乙醇胺并通过其氨基形成马来酰亚胺部分。马来酰亚胺基团是硫醇受体,而16:0 PE MCC是基于马来酰亚胺的脂化试剂。

应用

16:0 PE MCC(1,2-二棕榈酰-sn-甘油-3-磷酸乙醇胺-N-4-(马来酰亚胺基甲基)环己烷-羧酰胺)可用于:
  • 制备与人免疫缺陷病毒(HIV-1)包膜糖蛋白三聚体结合的脂质体
  • 制备寡核苷酸修饰囊泡
  • 扁平硅片的功能化
  • 脂质囊泡制备

生化/生理作用

功能化脂质体中的1,2-二棕榈酰基-sn-甘油-3-磷酸乙醇胺-N-[4-(马来酰亚胺基甲基)环己烷-羧酰胺](1,2-双(二苯基膦基)乙烷(DPPE)-MCC)有助于共价连接通过马来酰亚胺基团。它在肽转运研究中充当载体。

包装

5 mL透明玻璃密封安瓿(780200C-25mg)

象形图

Skull and crossbonesHealth hazard

警示用语:

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

靶器官

Central nervous system

储存分类代码

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

does not flash

闪点(°C)

does not flash

法规信息

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J T Elliott et al.
Bioconjugate chemistry, 11(6), 832-841 (2000-11-23)
Two maleimide-containing diacylglycerol derivatives were synthesized to permit the anchoring of short peptides and longer polypeptides to phospholipid bilayers and membranes. The maleimide was introduced at the site normally occupied by a phospholipid headgroup. The first lipid, the dipalmitoyl ester
Malin Edvardsson et al.
Analytical chemistry, 81(1), 349-361 (2008-11-28)
A novel setup was recently developed, combining quartz crystal microbalance with dissipation monitoring (QCM-D) and optical reflectometry for measurements on one and the same surface of, for example, biomolecular adlayers and interactions ( Rev. Sci. Instr. 2008 , 79 075107
Bärbel Lorenz et al.
Biophysical chemistry, 150(1-3), 54-63 (2010-03-12)
A versatile model system to study membrane-membrane interactions in great detail is introduced. Based on colloidal probe microscopy with membrane covered spherical probes attached to tip-less cantilevers the interaction forces and adhesion energies are quantified down to single molecule resolution.
Xiaoming Zhang et al.
Biochemical and biophysical research communications, 349(3), 920-924 (2006-09-15)
Human serum albumin (HSA) patterns have been successfully fabricated for the deposition of lipid bilayer, 1,2-dimyristoyl-sglycerophosphate (DMPA), by making use of the micro-contact printing (microCP) technique and liposome fusion. Confocal laser scanning microscopy (CLSM) results indicate that lipid bilayer has
K Gradauer et al.
Journal of controlled release : official journal of the Controlled Release Society, 172(3), 872-878 (2013-10-22)
The aim of the present study was the in vivo evaluation of thiomer-coated liposomes for an oral application of peptides. For this purpose, salmon calcitonin was chosen as a model drug and encapsulated within liposomes. Subsequently, the drug loaded liposomes

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