产品名称
转染试剂I, Avanti Research™ - A Croda Brand
packaging
pkg of 1 × 10 mg (790310P-10mg), pkg of 2 × 100 mg (790310P-200mg), pkg of 5 × 100 mg (790310P-500mg), pkg of 1 × 25 mg (790310P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
application(s)
advanced drug delivery
lipid type
cationic lipids
transfection
shipped in
dry ice
storage temp.
−20°C
form
powder
General description
转染试剂I包含阳离子脂质1,2-二油酰基氧基丙基）-N,N,N-三甲基氯化铵(DOTAP)和中性脂质DOPE（1,2-二油酰基-sn-甘油-3-磷酸乙醇胺）。DOTAP是一种具有双链季铵的表面活性剂。DOTAP/DOPE脂质体具有层状和倒六角形结构。
Application
转染试剂I已与胆固醇一起用于脂质体的制备，用于小鼠胚胎成纤维细胞中基于荧光的活细胞成像研究。它可用于将DNAzyme（Dz13）转染到静脉中。
Biochem/physiol Actions
转染试剂I用于大型单层阳离子脂质体(LUV)的制备和脂质复合物的产生。它提高了转染效率。DOTAP/DOPE（1,2-二油酰基氧基丙基）-N,N,N-三甲基氯化铵/（1,2-二油酰基-sn-甘油-3-磷酸乙醇胺）是用于人类给药的安全转染剂。它抑制血管增厚，是用于冠状动脉搭桥术(CABG)的有前途的候选药物。
Packaging
5 mL透明玻璃密封安瓿（790310P-10mg)
5 mL透明玻璃密封安瓿（790310P-200mg)
5 mL透明玻璃密封安瓿（790310P-25mg)
5 mL透明玻璃密封安瓿（790310P-500mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
flash_point_f
No data available
flash_point_c
No data available
Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene delivery
Roberts R, et al.
Autophagy, 9(5), 667-682 (2013)
Yue Li et al.
International journal of cardiology, 168(4), 3659-3664 (2013-07-28)
Coronary artery bypass grafting (CABG) is among the most commonly performed heart surgical procedures. Saphenous vein graft failure due to stenosis impedes the longer-term success of CABG. A key cellular event in the process of vein graft stenosis is smooth
Inhibition of vein graft stenosis with a c-jun targeting DNAzyme in a cationic liposomal formulation containing 1, 2-dioleoyl-3-trimethylammonium propane (DOTAP)/1, 2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)
Li Y, et al.
International Journal of Cardiology, 168(4), 3659-3664 (2013)
Rebecca Roberts et al.
Autophagy, 9(5), 667-682 (2013-02-21)
Cationic liposome (lipoplex) and polymer (polyplex)-based vectors have been developed for nonviral gene delivery. These vectors bind DNA and enter cells via endosomes, but intracellular transfer of DNA to the nucleus is inefficient. Here we show that lipoplex and polyplex
Bieong-Kil Kim et al.
Biochimica et biophysica acta, 1848(10 Pt A), 1996-2001 (2015-06-27)
The effects of lipid compositions on their physicochemical properties and transfection efficiencies were investigated. Four liposome formulations with different 1,2-dioleoyl-3-trimethylammoniumpropane (DOTAP) to dioleoylphosphatidylethanolamine (DOPE) weight ratios were investigated, that is, weight ratios 1:0 (T1P0), 3:1 (T3P1), 1:1 (T1P1), and 1:3
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