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经验公式（希尔记法）:
C53H100N5O13
化学文摘社编号:
分子量:
1015.39
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
18:1 DGS-NTA, 1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (ammonium salt), powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (790528P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 790528P
shipped in
dry ice
storage temp.
−20°C
Application
18:1 DGS-NTA 1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (ammonium salt) has been used:
- for generation of amphiphile monolayer
- in NTA-liposome preparation for procoagulant binding studies and to study its effect on factor FXII autoactivation
- as a liposome component for lipid bilayer preparation for surface plasmon resonance studies
Biochem/physiol Actions
1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (18:1 DGS-NTA or DOGS-NTA) cannot bind to histidine due to lack of nickel ion. It is capable of self-assembly to form a stable monolayer. DOGS-NTA ammonium salt is useful in bicelle preparation.
General description
1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (18:1 DGS-NTA) is amphiphile. DGS-NTA is a nitrilotriacetic acid -functionalized amphiphile devoid of nickel ion.
Packaging
5 mL Clear Glass Sealed Ampule (790528P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Louis Gioia et al.
Science immunology, 4(38) (2019-09-01)
The class II region of the major histocompatibility complex (MHC) locus is the main contributor to the genetic susceptibility to type 1 diabetes (T1D). The loss of an aspartic acid at position 57 of diabetogenic HLA-DQβ chains supports this association;
Ronald D Seidel et al.
Journal of the American Chemical Society, 129(15), 4834-4839 (2007-03-28)
The study of bound-state conformations of ligands interacting with proteins is important to the understanding of protein function and the design of drugs that alter function. Traditionally, transferred nuclear Overhauser effects (trNOEs), measured from NMR spectra of ligands in rapid
N J Mutch et al.
Journal of thrombosis and haemostasis : JTH, 10(10), 2108-2115 (2012-08-22)
Upon contact with an appropriate surface, factor XII (FXII) undergoes autoactivation or cleavage by kallikrein. Zn(2+) is known to facilitate binding of FXII and the cofactor, high molecular weight kininogen (HK), to anionic surfaces. To investigate whether transition metal ions
Decorating liquid crystal surfaces with proteins for real-time detection of specific protein-protein binding
Hartono D, et al.
Advances in Functional Materials, 19(22), 3574-3579 (2009)
N Bischler et al.
Biophysical journal, 74(3), 1522-1532 (1998-03-25)
Nickel-chelating lipid monolayers were used to generate two-dimensional crystals from yeast RNA polymerase I that was histidine-tagged on one of its subunits. The interaction of the enzyme with the spread lipid layers was found to be imidazole dependent, and the
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