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Merck
CN

791268P

Avanti

DTPA-BSA (Gd)

Avanti Research - A Croda Brand

别名:

(二亚乙基三胺五乙酸)-双(硬脂酰胺)(gd盐); Gd-DTPA-BSA

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关于此项目

经验公式(希尔记法):
C50H94GdN5O8
化学文摘社编号:
分子量:
1050.56
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
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产品名称

DTPA-BSA (Gd), DTPA-bis(stearylamide) (gadolinium salt), powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 mg (791268P-100mg)

manufacturer/tradename

Avanti Research - A Croda Brand 791268P

shipped in

dry ice

storage temp.

−20°C

General description

DTPA-BSA(Gd)(二乙烯三胺五乙酸-双(硬脂酰胺)(钆盐))是一种具有顺磁性的两亲分子。

Application

DTPA-BSA(Gd)(二乙烯三胺五乙酸-双(硬脂酰胺)(钆盐))已用于:
  • 制备非靶向(NT)钆修饰两亲性多肽胶束(PAM),用于动脉粥样硬化病变的磁共振成像(MRI)
  • 在小干扰RNA(siRNA)包埋类脂纳米粒(LLN)制备中用作MRI造影剂
  • 在顺磁性鞘脂激活蛋白C(saposin C)和二油酰磷脂酰丝氨酸(SapC-DOPS)囊泡的制备中作为MRI造影剂用于多形性胶质母细胞瘤(GBM)成像

Biochem/physiol Actions

Gd-DTPA-BSA可用作磁共振成像(MRI)造影剂,钆离子可缩短纵向弛豫时间使影像更为明亮。

Packaging

5 mL 棕色玻璃螺旋盖样品瓶 (791268P-100mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

存储类别

11 - Combustible Solids


历史批次信息供参考:

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Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents
Luo X, et al.
Nanoscale, 9(4), 1575-1579 (2017)
Sang Pil Yoo et al.
ACS omega, 1(5), 996-1003 (2016-12-06)
The leading causes of morbidity and mortality globally are cardiovascular diseases, and nanomedicine can provide many improvements including disease-specific targeting, early detection, and local delivery of diagnostic agents. To this end, we designed fibrin-binding, peptide amphiphile micelles (PAMs), achieved by
Imaging of brain tumors with paramagnetic vesicles targeted to phosphatidylserine
Winter PM, et al.
Journal of Magnetic Resonance Imaging : JMRI, 41(4), 1079-1087 (2015)
Geralda A F van Tilborg et al.
Bioconjugate chemistry, 17(3), 741-749 (2006-05-18)
Apoptosis, or programmed cell death, plays an important role in the etiology of a variety of diseases, including cancer and myocardial infarction. Visualization of apoptosis would allow both early detection of therapy efficiency and evaluation of disease progression. To that
X Luo et al.
Nanoscale, 9(4), 1575-1579 (2017-01-10)
Multi-functional nanomaterials possess unique properties, facilitating both therapeutic and diagnostic applications among others. Herein, we developed dual-functional lipid-like nanoparticles for simultaneous delivery of mRNA and magnetic resonance imaging (MRI) contrast agents in order to express functional proteins and provide real-time

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