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经验公式（希尔记法）:
C25H40N4O5
化学文摘社编号:
分子量:
476.61
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
12-NBD Stearate, Avanti Research™ - A Croda Brand, powder
SMILES string
[N+](=O)([O-])c1c2n[o]nc2c(cc1)N(C(CCCCCCCCCCC(=O)O)CCCCCC)C
InChI
1S/C25H40N4O5/c1-3-4-5-12-15-20(16-13-10-8-6-7-9-11-14-17-23(30)31)28(2)21-18-19-22(29(32)33)25-24(21)26-34-27-25/h18-20H,3-17H2,1-2H3,(H,30,31)
InChI key
SAAVELCIPHKGJE-UHFFFAOYSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810110P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
fluorescent lipids
shipped in
dry ice
storage temp.
−20°C
Application
12-NBD Stearate has been used in the fluorescent labeling of omega-3 fatty acid in biomaterial films and as a ligand for fatty acid binding protein 5 (FABP5) in competitive binding based high throughput fluorescence displacement assay. It may be used a ligand fluorescence displacement assay of fatty-acid binding protein 5 (FABP5).
Biochem/physiol Actions
12-NBD Stearate incorporated in lipid droplets and is used majorly in fluorescence displacement binding studies of fatty-acid binding proteins. The sterol carrier protein-2 (SCP-2) 15-kDa isoform favours NBD Stearate transport. The uptake of NBD Stearate is regulated by fatty acid binding protein (FABP) expression regulates uptake and inhibited by filipin III.
General description
12-NBD Stearate is amphipathic, nonesterifiable fluorescent fatty acid probe and is a long-chain fatty acid (LCFA) derivative.
Packaging
5 mL Amber Glass Screw Cap Vial (810110P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
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ACS infectious diseases, 6(4), 637-648 (2020-02-14)
Assembly of the bacterial cell wall requires not only the biosynthesis of cell wall components but also the transport of these metabolites to the cell exterior for assembly into polymers and membranes required for bacterial viability and virulence. LprG is
Targeting fatty acid binding protein (FABP) anandamide transporters-a novel strategy for development of anti-inflammatory and anti-nociceptive drugs
Berger WT, et al.
PLoS ONE, 7(12) (2012)
Tracking of drug release and material fate for naturally derived omega-3 fatty acid biomaterials
Faucher KM, et al.
Annals of Biomedical Engineering, 44(3), 782-792 (2016)
B P Atshaves et al.
The American journal of physiology, 274(3 Pt 1), C633-C644 (1998-04-08)
The effect of cellular differentiation on fatty acid uptake and intracellular diffusion was examined in transfected pluripotent mouse embryonic stem (ES) cells stably expressing intestinal fatty acid binding protein (I-FABP). Control ES cells, whether differentiated or undifferentiated, did not express
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