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别名:
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)2000-N′-carboxyfluorescein] (ammonium salt)
CAS号:
NACRES:
NA.25
检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 1 mg (810120P-1mg)
pkg of 1 × 500 μg (810120P-500ug)
manufacturer/tradename
Avanti Polar Lipids 810120P
运输
dry ice
储存温度
−20°C
一般描述
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)2000-N′-carboxyfluorescein] (18:0 PEG2000 PE CF) lipid comprises hydrophilic polyethylene glycol (PEG) polymer in its head groups. DSPE-PEG(2000) micelles exist as spheroid in aqueous solution.
应用
18:0 PEG2000 PE CF may be used:
- in in vitro release assays from nanoemulsion (NE)
- for the labeling PEGylated LPD (liposome-polycation-DNA) for size exclusion chromatography studies
- as a fluorescent probe to monitor shape transformation in giant vesicles
生化/生理作用
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)2000-N′-carboxyfluorescein] (18:0 PEG2000 PE CF) micelles aid in nanoparticles based drug delivery. It has potential to solubilize hydrophobic drugs and aid in the controlled release of drugs. 18:0 PEG2000 PE CF also called the DSPE−PEG2000, prevents the uptake of drugs by mononuclear phagocyte system and is a potential drug carrier for cancer therapy.
包装
5 mL Clear Glass Sealed Ampule (810120P-1mg)
5 mL Clear Glass Sealed Ampule (810120P-500ug)
储存分类代码
11 - Combustible Solids
法规信息
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示例
T1503
货号
-
25G
包装规格/数量
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705578-5MG-PW
PL860-CGA/SHF-1EA
MMYOMAG-74K-13
1000309185
输入内容 1.000309185)
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Shape Transformations of Lipid Vesicles by Insertion of Bulky-Head Lipids
Tsuda S, et al.
PLoS ONE, 10(7), e0132963-e0132963 (2015)
Nanoparticles evading the reticuloendothelial system: role of the supported bilayer
Li SD and Huang L
Biochimica et Biophysica Acta - Biomembranes, 1788(10), 2259-2266 (2009)
Molecular-matched materials for anticancer drug delivery and imaging
Wang D, et al.
Nanomedicine : nanotechnology, biology, and medicine, 10(19), 3003-3013 (2015)
Repeated injections of PEG-PE liposomes generate anti-PEG antibodies
Sroda K, et al.
Cellular & Molecular Biology Letters, 10, 37-47 (2005)
Characterization of 1, 2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[Methoxy (polyethylene glycerol)-2000] and Its Complex with Doxorubicin Using Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics
Hu W, et al.
Bioconjugate Chemistry, 28(6), 1777-1790 (2017)
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