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经验公式（希尔记法）:
C35H62N5O11P
化学文摘社编号:
分子量:
759.87
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
14:0-12:0 NBD PA, Avanti Research™ - A Croda Brand 810172P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810172P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810172P
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
Phosphatidic acid (PA) serves as a parent compound to generate other phospholipids. It is a major signaling molecule in the regulation of cellular processes including cell proliferation, secretion and reproduction, cytoskeletal organization, and many more.
General description
Phosphatidic acid (PA) is an anionic phospholipid with a phosphomonoester polar head group and two long hydrophobic acyl chains. It constitutes 1-4% of membrane lipids. NBD PA possess fluorescence analog, 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) at sn-2 fatty acid of PA.
Packaging
5 mL Amber Glass Screw Cap Vial (810172P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Phosphatidic acid in membrane rearrangements
Zhukovsky MA, et al.
Febs Letters, 593(17), 2428-2451 (2019)
Mikhail A Zhukovsky et al.
FEBS letters, 593(17), 2428-2451 (2019-08-01)
Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique biophysical properties: a small headgroup; negative charge; and a phosphomonoester group. Upon interaction with lysine or arginine, PA charge increases from -1 to -2 and this change stabilizes protein-lipid
A Chauhan et al.
Neurochemical research, 25(3), 423-429 (2000-04-13)
Fibrillar amyloid beta-protein (Abeta) is the major protein of amyloid plaques in the brains of patients with Alzheimer's disease (AD). The mechanism by which normally produced soluble Abeta gets fibrillized in AD is not clear. We studied the effect of
Interaction of amyloid beta-protein with anionic phospholipids: possible involvement of Lys28 and C-terminus aliphatic amino acids
Chauhan A, et al.
Neurochemical Research, 25(3), 423-429 (2000)
Karen M Henkels et al.
Oncotarget, 7(30), 47002-47017 (2016-06-04)
The intracellular concentration of the mitogen phosphatidic acid (PA) must be maintained at low levels until the need arises for cell proliferation. How temporal and spatial trafficking of PA affects its target proteins in the different cellular compartments is not
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