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Merck
CN

810189P

Avanti

TopFluor™ PI(3,4,5)P3

Avanti Research™ - A Croda Brand

别名:

1-oleoyl-2-{12-[4-(dipyrrometheneboron difluoride)butanoyl]amino}dodecanoyl-sn-glycero-3-phosphoinositol-3,4,5-trisphosphate (ammonium salt)

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关于此项目

经验公式（希尔记法）:
C56H108 BF2 N7O23P4
化学文摘社编号:
2260795-37-5
分子量:
1420.19
MDL number:
MFCD00036905
NACRES:
NA.25
UNSPSC Code:
12352211

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产品名称

TopFluor™ PI(3,4,5)P3, Avanti Research™ - A Croda Brand 810189P, powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 50 μg (with stopper and crimp cap (810189P-50ug))

manufacturer/tradename

Avanti Research™ - A Croda Brand 810189P

shipped in

dry ice

storage temp.

−20°C

General description

PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) is restricted to the cell membrane of inner leaflet. TopFluor™ PI(3,4,5)P3 is a fluorescently labeled-phosphoinositide derivative containing saturated acyl chain.
Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) is an inadequate phospholipid present on the inner leaflet of the plasma membrane.

Biochem/physiol Actions

PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) serves as a substrate for PTEN (phosphatase and tensin homolog), a tumor suppressor protein. It has binding affinity towards the active site of phosphatase domain. TopFluor™ PI(3,4,5)P3 might be useful in monitoring protein induced phosphoinositide clustering. This product is considered photostable than other fluorophores.
Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) plays a key role in inducing the cluster of Syntaxin1A at presynaptic terminals. It also regulates the activity protein kinase B/Akt.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (810189P-50ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Synaptic PI(3,4,5)P3 Is Required for Syntaxin1A Clustering and Neurotransmitter Release
Khuong TM, et al.
Neuron, 77(6), 1097-1108 (2013)
PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
Ebner M, et al.
Molecular Cell, 65(3), 416-431 (2017)
Biophysical methods for the characterization of PTEN/lipid bilayer interactions
Harishchandra RK, et al.
Methods, 125-125 (2015)
Biophysical methods for the characterization of PTEN/lipid bilayer interactions
Harishchandra RK, et al.
Methods, 77, 125-135 (2015)

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