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关于此项目
经验公式（希尔记法）:
C24H40N5O8P
化学文摘社编号:
分子量:
557.58
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
NBD Sphingosine-1-Phosphate, Avanti Research™ - A Croda Brand 810207X
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (810207X-100ug)
pkg of 1 × 1 mL (810207X-50ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810207X
concentration
0.05 mg/mL (810207X-50ug)
0.1 mg/mL (810207X-100ug)
shipped in
dry ice
storage temp.
−20°C
Application
NBD sphingosine-1-phosphate has been used as a substrate in the detection of sphingosine-1-phosphate phosphatases (SPPase) enzymatic activity by in vitro assay.
Biochem/physiol Actions
Sphingosine-1-phosphate (S1P) initiates DNA synthesis. It is also involved in cell division, cell growth and platelet activation. S1P mediates cell movement, differentiation and survival. It specifically stimulates endothelial cells.
General description
Sphingosine-1-phosphate is a phosphorylated sphingosine analog and is polar. It is terminally labelled by fluorescent nitrobenzo-2-oxa-1,3-diazole (NBD) group. Sphingosine-1-phosphate is abundantly stored in platelets.
Packaging
5 mL Amber Glass Screw Cap Vial (810207X-100ug)
5 mL Amber Glass Screw Cap Vial (810207X-50ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 1 - STOT SE 3
target_organs
Central nervous system
存储类别
3 - Flammable liquids
wgk
WGK 3
法规信息
易制毒化学品（2类）
危险化学品
此项目有
Synthesis of fluorescence-labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior
Hakogi T, et al.
Bioorganic & Medicinal Chemistry Letters, 13(4), 661-664 (2003)
Sphingosine-1-phosphate phosphatase 2 regulates pancreatic islet beta-cell endoplasmic reticulum stress and proliferation
Taguchi Y, et al.
The Journal of Biological Chemistry, 291(23), 12029-12038 (2016)
Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes
Ito K, et al.
Biochemical and biophysical research communications, 357(1), 212-217 (2007)
Gaelen S Smith et al.
Biomolecules, 3(3), 351-368 (2014-03-13)
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that activates a family of G protein coupled-receptors (GPCRs) implicated in mammalian development, angiogenesis, immunity and tissue regeneration. S1P functions as a trophic factor for many cell types, including embryonic stem cells (ESCs). Sphingosine
Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function.
Serra M and Saba JD
Advances in Enzyme Regulation, 50(1), 349-362 (2010)
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