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Merck
CN

810211C

Avanti

C12-NBD Ceramide

Avanti Research™ - A Croda Brand

别名:

N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-D-erythro-sphingosine

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关于此项目

经验公式（希尔记法）:
C36H61N5O6
CAS Number:
202850-01-9
分子量:
659.90
MDL编号:
MFCD02259239
UNSPSC代码:
12352211
NACRES:
NA.25

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Product Name

C12-NBD Ceramide, Avanti Research™ - A Croda Brand 810211C

方案

>99% (TLC)

表单

liquid

包装

pkg of 1 × 1 mL (810211C-1mg)

制造商/商品名称

Avanti Research™ - A Croda Brand 810211C

浓度

1 mg/mL (810211C-1mg)

运输

dry ice

储存温度

−20°C

SMILES字符串

[N+](=O)([O-])c1c2n[o]nc2c(cc1)NCCCCCCCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO

InChI

1S/C36H61N5O6/c1-2-3-4-5-6-7-8-9-10-12-15-18-21-24-33(43)31(29-42)38-34(44)25-22-19-16-13-11-14-17-20-23-28-37-30-26-27-32(41(45)46)36-35(30)39-47-40-36/h21,24,26-27,31,33,37,42-43H,2-20,22-23,25,28-29H2,1H3,(H,38,44)/b24-21+/t31-,33+/m0/s1

InChI key

SNOJCYCOPNIGIK-ULETYAGTSA-N

相关类别

应用

C12-NBD ceramide is suitable for its use:
  • as a substrate to measure the activity of acid, alkaline and neutral ceramidases
  • in in vitro ceramidase activity assay
  • in ceramide phosphoethanolamine (CPE) synthase assay to determine the Km and Vmax of sphingomyelin synthase (SMS1, SMS2, and SMSr)

生化/生理作用

Ceramide is one of the products of sphingolipid metabolism. The members of ceramide synthase family are responsible for its synthesis. Each ceramide synthesized differs in its acyl chain length. Ceramides possess a wide range of functions, associated with apoptosis, cancer inhibition and chemotherapy. Its action is also related to neurodegenerative diseases.

包装

5 mL Amber Glass Screw Cap Vial (810211C-1mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

靶器官

Central nervous system

WGK

WGK 3

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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A Critical Role for Ceramide Synthase 2 in Liver Homeostasis I. ALTERATIONS IN LIPID METABOLIC PATHWAYS
Pewzner JY, et al.
The Journal of Biological Chemistry, 285(14), 10902-10910 (2010)
The ATP-binding cassette transporter-2 (ABCA2) overexpression modulates sphingosine levels and transcription of the amyloid precursor protein (APP) gene
Davis W
Current Alzheimer Research, 12(9), 847-859 (2015)
All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity
Ding T, et al.
Journal of Lipid Research, 56(3), 537-545 (2015)
Mammalian ceramide synthases
Levy M and Futerman AH
IUBMB Life, 62(5), 347-356 (2010)
Li-Yu Chen et al.
Nature communications, 6, 6030-6030 (2015-01-17)
Turgor pressure plays pivotal roles in the growth and movement of walled cells that make up plants and fungi. However, the molecular mechanisms regulating turgor pressure and the coordination between turgor pressure and cell wall remodelling for cell growth remain

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