登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C36H61N5O6
化学文摘社编号:
分子量:
659.90
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
C12-NBD Ceramide, Avanti Research™ - A Croda Brand 810211P, powder
SMILES string
[N+](=O)([O-])c1c2n[o]nc2c(cc1)NCCCCCCCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO
InChI
1S/C36H61N5O6/c1-2-3-4-5-6-7-8-9-10-12-15-18-21-24-33(43)31(29-42)38-34(44)25-22-19-16-13-11-14-17-20-23-28-37-30-26-27-32(41(45)46)36-35(30)39-47-40-36/h21,24,26-27,31,33,37,42-43H,2-20,22-23,25,28-29H2,1H3,(H,38,44)/b24-21+/t31-,33+/m0/s1
InChI key
SNOJCYCOPNIGIK-ULETYAGTSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810211P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810211P
shipped in
dry ice
storage temp.
−20°C
Application
C12-NBD Ceramide or N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-D-erythro-sphingosine has been used as a substrate in ceramidase activity assay. It is also suitable for the lipid binding assays and in cell culture experiments for endothelial cells to determine the pro-apoptotic intracellular ceramide generation.
Biochem/physiol Actions
C12-7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) Ceramide is useful for measuring the alkaline and neutral ceramidase activity. It is involved in maintainingthe physical properties of ceramide required for cellular studies.
General description
C12 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) ceramide is a long-chain fluorescent phospholipid. It is a natural analog of ceramide with C12 acyl chain length.
Packaging
5 mL Amber Glass Screw Cap Vial (810211P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Megha et al.
Biochimica et biophysica acta, 1768(9), 2205-2212 (2007-06-19)
Ceramides are sphingolipids that greatly stabilize ordered membrane domains (lipid rafts), and displace cholesterol from them. Ceramide-rich rafts have been implicated in diverse biological processes. Because ceramide analogues have been useful for probing the biological function of ceramide, and may
Terry R Medler et al.
American journal of respiratory cell and molecular biology, 38(6), 639-646 (2008-01-15)
The de novo pathway of ceramide synthesis has been implicated in the pathogenesis of excessive lung apoptosis and murine emphysema. Intracellular and paracellular-generated ceramides may trigger apoptosis and propagate the death signals to neighboring cells, respectively. In this study we
Effect of ceramide N-acyl chain and polar headgroup structure on the properties of ordered lipid domains (lipid rafts)
Meghan PS, et al.
Biochimica et Biophysica Acta, 1768(9), 2205-2212 (2007)
M Tani et al.
Journal of biochemistry, 125(4), 746-749 (1999-04-02)
A fluorescent analogue of ceramide, C12-NBD-ceramide, was found to be hydrolyzed much faster than 14C-labeled ceramide by alkaline ceramidase from Pseudomonas aeruginosa and neutral ceramidase from mouse liver, while this substrate was relatively resistant to acid ceramidase from plasma of
VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites
Nikit K, et al.
The Journal of Cell Biology, 217(10), 3625-3639 (2018)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持