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关于此项目
经验公式（希尔记法）:
C36H63N5O7
化学文摘社编号:
分子量:
677.91
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
C12-NBD Phytosphingosine, Avanti Research™ - A Croda Brand
description
N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-phytosphingosine
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 50 μg (810215P-50ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
SMILES string
N[C@H]([C@H](O)[C@H](O)CCCCCCCCCCCCCC)CO
InChI
1S/C18H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20/h16-18,20-22H,2-15,19H2,1H3/t16-,17+,18-/m0/s1
InChI key
AERBNCYCJBRYDG-KSZLIROESA-N
General description
C12-NBD Phytosphingosine is a fluorescent derivative of the naturally occurring lipid compound, phytosphingosine which is localised in skin, kidney and intestines.
Phytosphingosine is a ceramide molecule localized to the stratum corneum.
Application
C12-NBD Phytosphingosine has been used as a substrate in ceramidase activity assay to study enzyme activity.
C12-NBD phytosphingosine has been used as a substrate to assay ceramidase activity.
Biochem/physiol Actions
In vitro studies using human epidermis model shows that melanin production is prevented by phytosphingosine. Hence, it is widely used in cosmetics.
Phytosphingosine (PHS) is a sphingoid lipid molecule which is known to exhibit antimicrobial and anti-inflammatory action. PHS can has the ability to increase the production of keratinocyte differentiation marker proteins, such as transglutaminase 1 and involucrin, that are responsible for the development of cornifed envelope. PHS metabolism results in the formation of glycerophospholipids, sphingolipids and even-numbered fatty acids which mainly include palmitic acid.
Packaging
5 mL Amber Glass Screw Cap Vial (810215P-50ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
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存储类别
11 - Combustible Solids