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经验公式(希尔记法):
C35H61N6O9P
化学文摘社编号:
分子量:
740.87
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
C6-NBD鞘磷脂, Avanti Research™ - A Croda Brand 810218P, powder
SMILES string
[P](=O)([O-])(OC[C@H](NC(=O)CCCCCNc1c2n[o]nc2c(cc1)[N+](=O)[O-])[C@H](O)\C=C\CCCCCCCCCCCCC)OCC[N+](C)(C)C
InChI
1S/C35H61N6O9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-18-21-32(42)30(28-49-51(46,47)48-27-26-41(2,3)4)37-33(43)22-19-17-20-25-36-29-23-24-31(40(44)45)35-34(29)38-50-39-35/h18,21,23-24,30,32,42H,5-17,19-20,22,25-28H2,1-4H3,(H2-,36,37,39,43,46,47)/b21-18+/t30-,32+/m0/s1
InChI key
YDBDYTGWMRUUSN-PERJAUJZSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810218P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810218P
shipped in
dry ice
storage temp.
−20°C
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Application
C6-NBD鞘磷脂适用于内吞作用测定。
Biochem/physiol Actions
鞘磷脂控制细胞生长、分化、凋亡和沿膜的信号转导。已知其可防止结肠肿瘤的增殖。鞘磷脂还抑制胆固醇吸收。鞘磷脂的异常积累导致尼曼匹克病。
General description
鞘磷脂是具有中央鞘氨醇和酰胺连接的脂肪酸的膜磷脂。磷酸胆碱形成极性头基。它是乳脂肪球膜中的主要磷脂之一。
Packaging
5 mL琥珀色玻璃螺旋盖小瓶(810218P-1mg)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dauner K, et al.
The Journal of biological chemistry, 292(14), 5737-5747 (2017)
Mark L Schultz et al.
BMC medicine, 17(1), 200-200 (2019-11-13)
Niemann-Pick disease type C is a fatal and progressive neurodegenerative disorder characterized by the accumulation of unesterified cholesterol in late endosomes and lysosomes. We sought to develop new therapeutics for this disorder by harnessing the body's endogenous cholesterol scavenging particle
Avery L McIntosh et al.
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