810251P
Avanti
NBD-6 Cholesterol
Avanti Research™ - A Croda Brand
别名:
5-cholesten-3β-ol 6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]caproate
产品名称
NBD-6 Cholesterol, Avanti Research™ - A Croda Brand 810251P, powder
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 1 mg (810251P-1mg)
pkg of 1 × 5 mg (810251P-5MG)
制造商/商品名称
Avanti Research™ - A Croda Brand 810251P
运输
dry ice
储存温度
−20°C
一般描述
NBD-6 Cholesterol is a fluorescent analog of the lipoprotein compound cholesterol, with NBD (2-(4-nitro-2,1,3-benzoxadiazol-7-yl) aminoethyl) being the fluorescent group.
应用
NBD-6 Cholesterol has been used for NBD-cholesterol binding assay, to study the binding of fluorescent NBD cholesterol in the binding pocket concerning ASTER domains.
生化/生理作用
Cholesterol is produced from acetyl-CoA by a complex multistep mevalonate pathway. In mammals, liver is the main site of de novo cholesterol synthesis contributing to almost 80% of total cholesterol synthesis. Cholesterol and its metabolites, along with its precursors, play important roles in cellular membrane physiology. They also have roles in reproductive biology, dietary nutrient absorption, stress responses, salt and water balance and calcium metabolism.
包装
5 mL Amber Glass Screw Cap Vial (810299P-1MG)
5 mL Amber Glass Screw Cap Vial (810251P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
No data available
闪点(°C)
No data available
Fluorescent and Luminescent Probes for Biological Activity (1999)
Molecular Nutrition And Food Research, 277-290 (2016)
Pedro M R Cruz et al.
Frontiers in pharmacology, 4, 119-119 (2013-10-05)
While the unique metabolic activities of malignant tissues as potential targets for cancer therapeutics has been the subject of several recent reviews, the role of cholesterol metabolism in this context is yet to be fully explored. Cholesterol is an essential
Cholesterol in health and disease.
Ira Tabas
The Journal of clinical investigation, 110(5), 583-590 (2002-09-05)
Jaspreet Sandhu et al.
Cell, 175(2), 514-529 (2018-09-18)
The mechanisms underlying sterol transport in mammalian cells are poorly understood. In particular, how cholesterol internalized from HDL is made available to the cell for storage or modification is unknown. Here, we describe three ER-resident proteins (Aster-A, -B, -C) that
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