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关于此项目
经验公式（希尔记法）:
C48H80N3O8F2
化学文摘社编号:
分子量:
865.16
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
C11 TopFluor™ Glucosyl Ceramide, Avanti Research™ - A Croda Brand 810267P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 250 μg (810267P-250ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810267P
shipped in
dry ice
storage temp.
−20°C
General description
Glucosyl Ceramide (GlcCer)/cerebroside/galactosylceramide is a neutral, polar lipid. It can be ionized delicately in negative-and positive-ion modes. It is the simplest glycosphingolipids (GSLs), that is present abundantly in the mammalian tissues. GlcCer is produced through glycosylation of Cer with the help of GlcCer synthase (GCS) at the cytosolic leaflet of Golgi apparatus.
Application
C11 TopFluor™ Glucosyl Ceramide is suitable to use as a label in the GLM II model and as a component in the usual giant unilamellar vesicle (GUV) lipid mixture (GLM).
Biochem/physiol Actions
Glucosyl ceramide (GlcCer) plays a major role in the pathways of glycosphingolipid metabolism. It helps to modulate cell physiology. It acts as an intracellular messenger in cell maintenance and regulation.
Packaging
5 mL Amber Glass Screw Cap Vial (810267P-250ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
法规信息
涉药品监管产品
此项目有
Characterization of Lipids by Electrospray Ionization Mass Spectrometry, Lipid Analysis
Lipid analysis (2012)
Effect of glucosylceramide on the biophysical properties of fluid membranes
Varela ARP, et al.
Biochimica et Biophysica Acta - Biomembranes, 1828(3), 1122-1130 (2013)
Lipid segregation and membrane budding induced by the peripheral membrane binding protein annexin A2
Drucker P, et al.
Test, 288(34), 24764-24776 (2013)
Omid Motabar et al.
Analytical and bioanalytical chemistry, 402(2), 731-739 (2011-10-29)
Glucocerebrosidase is a lysosomal enzyme that catalyzes the hydrolysis of glucosylceramide to form ceramide and glucose. A deficiency of lysosomal glucocerebrosidase due to genetic mutations results in Gaucher disease, in which glucosylceramide accumulates in the lysosomes of certain cell types.
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