810270P
Avanti
C11 TopFluor™ Ceramide-1-Phosphate
Avanti Research™ - A Croda Brand
别名:
N-[11-(TopFluor)undecanoyl]-D-ceramide-1-phosphate (ammonium salt)
产品名称
C11 TopFluor™ Ceramide-1-Phosphate, N-[11-(dipyrrometheneboron difluoride)undecanoyl]-D-erythro-sphingosine-1-phosphate (ammonium salt), powder
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 250 μg (810270P-250ug)
制造商/商品名称
Avanti Research™ - A Croda Brand 810270P
运输
dry ice
储存温度
−20°C
一般描述
Ceramide-1-phosphate (C1P), an anti-apoptotic lipid is produced with the help of ceramide kinase (CERK) by the direct phosphorylation of ceramide.
The availability of this new fluorescent metabolite provides the researcher with new ways to track cell migration and G protein coupled activity.
应用
C11 TopFluor™ Ceramide-1-Phosphate may be used to study its effect on the migration of pancreatic cancer stem cells (PCSC) using confocal microscopy.
生化/生理作用
Ceramide-1-phosphate (C1P) is capable of blocking cell death in bone marrow-derived macrophages (BMDMs). It controls the growth and survival in various cell types. C1P bioactive sphingolipid is known to modulate the proliferation and differentiation of photoreceptors. C1P controls apoptosis. It acts as a pro-inflammatory agent and plays a key role in phagocytosis. Ceramide-1-phosphate is well known as a second messenger and an important mediator of inflammatory response.
包装
5 mL Amber Glass Screw Cap Vial (810270P-250ug)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
No data available
闪点(°C)
No data available
法规信息
新产品
此项目有
Carolyn M Shirey et al.
Chemistry and physics of lipids, 200, 32-41 (2016-10-26)
Ceramide-1-phosphate (C1P) is an important signaling sphingolipid and a metabolite of ceramide. C1P contains an anionic phosphomonoester head group and has been shown to regulate physiological and pathophysiological processes such as cell proliferation, inflammation, apoptosis, phagocytosis, and macrophage chemotaxis. Despite
Ceramide-1-Phosphate, a New Mediator of Development and Survival in Retina Photoreceptors
Miranda GE, et al.
Investigative Ophthalmology & Visual Science, 52(9), 6580-6588 (2011)
The Role of Ceramide-1-Phosphate in Biological Functions
Handbook of Experimental Pharmacology, 153-153 (2013)
Ceramide and ceramide 1-phosphate in health and disease
Arana L, et al.
Lipids in Health and Disease, 9(1), 1-12 (2010)
Ceramide-1-phosphate in cell survival and inflammatory signaling
Gomez MA, et al.
Advances in Experimental Medicine and Biology, 118-130 (2010)
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