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关于此项目
经验公式（希尔记法）:
C42H74BF2N4O6P
化学文摘社编号:
分子量:
810.84
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
C11 TopFluor™ Ceramide-1-Phosphate, N-[11-(dipyrrometheneboron difluoride)undecanoyl]-D-erythro-sphingosine-1-phosphate (ammonium salt), powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 250 μg (810270P-250ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810270P
shipped in
dry ice
storage temp.
−20°C
General description
Ceramide-1-phosphate (C1P), an anti-apoptotic lipid is produced with the help of ceramide kinase (CERK) by the direct phosphorylation of ceramide.
The availability of this new fluorescent metabolite provides the researcher with new ways to track cell migration and G protein coupled activity.
Application
C11 TopFluor™ Ceramide-1-Phosphate may be used to study its effect on the migration of pancreatic cancer stem cells (PCSC) using confocal microscopy.
Biochem/physiol Actions
Ceramide-1-phosphate (C1P) is capable of blocking cell death in bone marrow-derived macrophages (BMDMs). It controls the growth and survival in various cell types. C1P bioactive sphingolipid is known to modulate the proliferation and differentiation of photoreceptors. C1P controls apoptosis. It acts as a pro-inflammatory agent and plays a key role in phagocytosis. Ceramide-1-phosphate is well known as a second messenger and an important mediator of inflammatory response.
Packaging
5 mL Amber Glass Screw Cap Vial (810270P-250ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
法规信息
新产品
此项目有
Ceramide-1-phosphate in cell survival and inflammatory signaling
Gomez MA, et al.
Advances in Experimental Medicine and Biology, 118-130 (2010)
Carolyn M Shirey et al.
Chemistry and physics of lipids, 200, 32-41 (2016-10-26)
Ceramide-1-phosphate (C1P) is an important signaling sphingolipid and a metabolite of ceramide. C1P contains an anionic phosphomonoester head group and has been shown to regulate physiological and pathophysiological processes such as cell proliferation, inflammation, apoptosis, phagocytosis, and macrophage chemotaxis. Despite
Ceramide and ceramide 1-phosphate in health and disease
Arana L, et al.
Lipids in Health and Disease, 9(1), 1-12 (2010)
The Role of Ceramide-1-Phosphate in Biological Functions
Handbook of Experimental Pharmacology, 153-153 (2013)
Ceramide-1-Phosphate, a New Mediator of Development and Survival in Retina Photoreceptors
Miranda GE, et al.
Investigative Ophthalmology & Visual Science, 52(9), 6580-6588 (2011)
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