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关于此项目
经验公式（希尔记法）:
C46H80BF2N4O10P
化学文摘社编号:
分子量:
928.93
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
TopFluor™ PS, Avanti Research™ - A Croda Brand 810283P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810283P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810283P
shipped in
dry ice
storage temp.
−20°C
Packaging
5 mL Amber Glass Screw Cap Vial (810283P-1mg)
Application
TopFluor™ PS may be used in liposome generation and as a synthetic fluorescent phosphoserine (PS) analogue to study PS distribution and dynamics in mouse embryonic fibroblasts (MEFs). It has also been used in the preparation of donor liposomes.
Biochem/physiol Actions
Phosphoserine (PS) can be used as a template for the recognition of cancer antigen 125 (CA 125). It is very essential for healthy nerve cell membranes and myelin. PS actively participates in the locomotor functions, like rapid reactions and reflexes.
General description
TopFluor™, a fluorescent molecule carries dipyrromethene boron difluoride moiety. It is linked to several lipid molecules by means of covalent attachment. Phosphoserine/phosphatidylserine (PS) is an endogenous phospholipid, that is found in all polyanionic macromolecules.
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Deficient endoplasmic reticulum-mitochondrial phosphatidylserine transfer causes liver disease
Hernandez-Alvarez MI, et al.
Cell, 177(4), 881-895 (2019)
Phosphatidylserine dynamics in cellular membranes
Kay JG, et al.
Molecular Biology of the Cell, 23(11), 2198-2212 (2012)
Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies
Conrad KS, et al.
Nature Communications, 8(1908), 1-13 (2017)
Investigation of the biophysical properties of a fluorescently modified ceramide-1-phosphate
Shirey CM, et al.
Chemistry and Physics of Lipids, 200, 32-32 (2016)
Adsorption of O-phospho-L-serine and L-serine onto poorly crystalline apatite
Benaziz L, et al.
Journal of Colloid and Interface Science, 238(1), 48-53 (2001)
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