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关于此项目
经验公式（希尔记法）:
C39H82N7O20P3
化学文摘社编号:
分子量:
1062.02
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
产品名称
Click PI(4,5)P2-azido, Avanti Research™ - A Croda Brand 810340P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 100 μg (with stopper and crimp cap (810340P-100ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand 810340P
lipid type
click reagents
shipped in
dry ice
storage temp.
−20°C
General description
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is an anionic lipid and is present in the plasma membrane (PM).
Biochem/physiol Actions
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a lipid messenger. It controls exocytosis, actin cytoskeleton dynamics and endocytosis. It also plays a key role in signal transduction, vesicle trafficking and motility. The azido functional group in the lipid may involve in a copper-catalyzed reaction to form click reaction.
Packaging
2 mL Amber Serum Vial with Stopper and Crimp Cap (810340P-100ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
新产品
此项目有
Clickable lipids: azido and alkynyl fatty acids and triacylglycerols
Zerkowski JA, et al.
Journal of the American Oil Chemists' Society, 86(11), 1115-1115 (2009)
Xiaojun Tan et al.
Journal of cell science, 128(22), 4047-4056 (2015-11-18)
Phosphoinositides are a collection of lipid messengers that regulate most subcellular processes. Amongst the seven phosphoinositide species, the roles for phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] at the plasma membrane, such as in endocytosis, exocytosis, actin polymerization and focal adhesion assembly, have been
Analysis of Phosphatidic Acid Binding and Regulation of PIPKI In Vitro and in Intact Cells
Methods in Enzymology, 583, 359-374 (2017)
Arne Gericke et al.
Advances in experimental medicine and biology, 991, 85-104 (2013-06-19)
PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) is a relatively common anionic lipid that regulates cellular functions by multiple mechanisms. Hydrolysis of PtdIns(4,5)P2 by phospholipase C yields inositol trisphosphate and diacylglycerol. Phosphorylation by phosphoinositide 3-kinase yields PtdIns(3,4,5)P3, which is a potent signal for survival
PI(4,5)P2 controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites.
Mira Sohn et al.
The Journal of cell biology, 217(5), 1797-1813 (2018-02-24)
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a critically important regulatory lipid of the plasma membrane (PM); however, little is known about how cells regulate PM PI(4,5)P2 levels. Here, we show that the phosphatidylinositol 4-phosphate (PI4P)/phosphatidylserine (PS) transfer activity of the endoplasmic reticulum
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