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关于此项目
经验公式（希尔记法）:
C19H36O8PNa
化学文摘社编号:
分子量:
446.45
MDL number:
UNSPSC Code:
51191904
NACRES:
NA.25
产品名称
08:0 PA, 1,2-dioctanoyl-sn-glycero-3-phosphate (sodium salt), powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (830842P-10mg), pkg of 1 × 25 mg (830842P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 830842P
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[Na+]
InChI
1S/C19H37O8P.Na/c1-3-5-7-9-11-13-18(20)25-15-17(16-26-28(22,23)24)27-19(21)14-12-10-8-6-4-2;/h17H,3-16H2,1-2H3,(H2,22,23,24);/q;+1/p-1/t17-;/m1./s1
InChI key
ZNDNSOYDPUTHKQ-UNTBIKODSA-M
General description
Phosphatidic acid is obtained from glycerophospholipid with the help of phospholipase D. 08:0 PA/1,2-dioctanoyl-sn-glycero-3-phosphate (C8-PA) is an mammalian target of rapamycin (mTOR) activator.
Application
08:0 PA may be used to activate p-mTOR in order to assess whether the observed apoptotic effect of histone deacetylase inhibitors (HDACIs) is related to mammalian target of rapamycin (mTOR) pathway signaling.
Biochem/physiol Actions
Phosphatidic acid might serve as a modulator of phagocyte respiratory burst. It also acts as a precursor of diacylglycerol and lysophosphatidic acid. 08:0 PA/C8-PA has the ability to affect the phosphorylation of mammalian target of rapamycin (mTOR) and the viability of gallbladder carcinoma cells, that are treated with histone deacetylase inhibitors (HDACIs).
Packaging
5 mL Clear Glass Sealed Ampule (830842P-10mg)
5 mL Clear Glass Sealed Ampule (830842P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Histone deacetylase inhibitors inhibit the proliferation of gallbladder carcinoma cells by suppressing AKT/mTOR signaling
Zhang P, et al.
Testing, 10(8), e0136193-e0136193 (2015)
A Yalcin et al.
Oncogene, 29(1), 139-149 (2009-10-27)
Choline is an essential anabolic substrate for the synthesis of phospholipids. Choline kinase phosphorylates choline to phosphocholine that serves as a precursor for the production of phosphatidylcholine, the major phospholipid constituent of membranes and substrate for the synthesis of lipid
Hae-In Song et al.
Scientific reports, 6, 36968-36968 (2016-11-23)
Phospholipase D1 (PLD1) plays a known role in several differentiation processes, but its role in adipogenic differentiation remains unknown. In the present study, we identified PLD1 as a negative regulator of adipogenic differentiation. We showed that PLD activity was downregulated
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 830842P-10MG | 04061835228362 |