登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C19H36O8PNa
化学文摘社编号:
分子量:
446.45
MDL number:
UNSPSC Code:
51191904
NACRES:
NA.25
产品名称
08:0 PA, 1,2-dioctanoyl-sn-glycero-3-phosphate (sodium salt), powder
SMILES string
[H][C@@](COP([O-])(O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[Na+]
InChI
1S/C19H37O8P.Na/c1-3-5-7-9-11-13-18(20)25-15-17(16-26-28(22,23)24)27-19(21)14-12-10-8-6-4-2;/h17H,3-16H2,1-2H3,(H2,22,23,24);/q;+1/p-1/t17-;/m1./s1
InChI key
ZNDNSOYDPUTHKQ-UNTBIKODSA-M
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (830842P-10mg)
pkg of 1 × 25 mg (830842P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 830842P
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
Application
08:0 PA may be used to activate p-mTOR in order to assess whether the observed apoptotic effect of histone deacetylase inhibitors (HDACIs) is related to mammalian target of rapamycin (mTOR) pathway signaling.
Biochem/physiol Actions
Phosphatidic acid might serve as a modulator of phagocyte respiratory burst. It also acts as a precursor of diacylglycerol and lysophosphatidic acid. 08:0 PA/C8-PA has the ability to affect the phosphorylation of mammalian target of rapamycin (mTOR) and the viability of gallbladder carcinoma cells, that are treated with histone deacetylase inhibitors (HDACIs).
General description
Phosphatidic acid is obtained from glycerophospholipid with the help of phospholipase D. 08:0 PA/1,2-dioctanoyl-sn-glycero-3-phosphate (C8-PA) is an mammalian target of rapamycin (mTOR) activator.
Packaging
5 mL Clear Glass Sealed Ampule (830842P-10mg)
5 mL Clear Glass Sealed Ampule (830842P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Histone deacetylase inhibitors inhibit the proliferation of gallbladder carcinoma cells by suppressing AKT/mTOR signaling
Zhang P, et al.
Testing, 10(8), e0136193-e0136193 (2015)
A Yalcin et al.
Oncogene, 29(1), 139-149 (2009-10-27)
Choline is an essential anabolic substrate for the synthesis of phospholipids. Choline kinase phosphorylates choline to phosphocholine that serves as a precursor for the production of phosphatidylcholine, the major phospholipid constituent of membranes and substrate for the synthesis of lipid
Hae-In Song et al.
Scientific reports, 6, 36968-36968 (2016-11-23)
Phospholipase D1 (PLD1) plays a known role in several differentiation processes, but its role in adipogenic differentiation remains unknown. In the present study, we identified PLD1 as a negative regulator of adipogenic differentiation. We showed that PLD activity was downregulated
Glycerolipids in signal transduction
Lambeth JD and Ryu SH
New comprehensive biochemistry, 31, 237-255 (1996)
Jie Li et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 26(14), 3843-3855 (2020-04-29)
Although platinum compounds are the first-line treatment for ovarian cancer, the majority of patients relapse and develop resistance to treatment. However, the mechanism underlying resistance is unclear. The goal of our study is to decipher the mechanism by which a
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持