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关于此项目
经验公式（希尔记法）:
C39H76O8PNa
化学文摘社编号:
分子量:
726.98
MDL number:
UNSPSC Code:
51191904
NACRES:
NA.25
产品名称
18:0 PA, Avanti Research™ - A Croda Brand
SMILES string
[Na+].[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC)O
InChI
1S/C39H77O8P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h37H,3-36H2,1-2H3,(H2,42,43,44);/q;+1/p-1/t37-;/m1./s1
InChI key
ALPWRKFXEOAUDR-GKEJWYBXSA-M
description
1,2-distearoyl-sn-glycero-3-phosphate (sodium salt)
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 25 mg (830865P-25mg)
pkg of 1 × 500 mg (830865P-500mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
Application
18:0 PA可用于：
- 作为双层膜的成分，研究其对不同外壳蛋白I（COPI）裂变因子的囊泡形成能力，
- 研究其对C6大鼠胶质瘤和L2071小鼠成纤维细胞内Ca2+浓度（[Ca2+]i）的影响
- 研究其对细胞色素b（558）α链（p22phox）磷酸化的影响
Biochem/physiol Actions
磷脂酸（PA）充当生产膜甘油磷脂和三酰基甘油的生物合成前体。它参与调节哺乳动物雷帕霉素靶蛋白（mTOR）途径。它也可能参与膜运输，特别是膜融合和裂变。
General description
磷脂酸（PA）具有两个脂肪酸和一个磷酸盐，连接到甘油主链的磷酸盐。这两种脂肪酸存在于C原子的sn-1和sn-2位置，磷酸盐基存在于C原子的sn-3位置。
Packaging
20 mL透明玻璃螺旋盖小瓶（830865P-500mg）
5 mL棕色玻璃螺旋盖小瓶（830865P-25mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Emeline Tanguy et al.
Frontiers in cellular neuroscience, 13, 2-2 (2019-02-08)
Among the cellular lipids, phosphatidic acid (PA) is a peculiar one as it is at the same time a key building block of phospholipid synthesis and a major lipid second messenger conveying signaling information. The latter is thought to largely
Peter Bond
Nutrition & metabolism, 14, 12-12 (2017-02-12)
The mechanistic target of rapamycin complex 1 (mTORC1) has received much attention in the field of exercise physiology as a master regulator of skeletal muscle hypertrophy. The multiprotein complex is regulated by various signals such as growth factors, energy status
D S Regier et al.
The Journal of biological chemistry, 274(51), 36601-36608 (1999-12-14)
Using a phosphorylation-dependent cell-free system to study NADPH oxidase activation (McPhail, L. C., Qualliotine-Mann, D., and Waite, K. A. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7931-7935), we previously showed that p47(phox), a cytosolic NADPH oxidase component, is
Yang Liu et al.
Nature communications, 10(1), 5108-5108 (2019-11-11)
Mounting evidence suggests that the tumor microenvironment is profoundly immunosuppressive. Thus, mitigating tumor immunosuppression is crucial for inducing sustained antitumor immunity. Whereas previous studies involved intratumoral injection, we report here an inhalable nanoparticle-immunotherapy system targeting pulmonary antigen presenting cells (APCs)
Young-Ja Chang et al.
Prostaglandins & other lipid mediators, 83(4), 268-276 (2007-05-15)
Phosphatidic acid (PA) increased intracellular Ca(2+) concentration ([Ca(2+)](i)) in C6 rat glioma and L2071 mouse fibroblast cells. Dioleoyl PA (PA, 18:1) was the most efficacious, followed by dipalmitoyl PA (16:0 PA) and dimyristoyl PA (14:0 PA). Lysophosphatidic acid (LPA) also
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