产品名称
Lyso PAF (from Heart PC), Avanti Research™ - A Croda Brand 840008P, powder
SMILES string
O[C@](COP([O-])(OCC[N+](C)(C)C)=O)([H])COCCCCCCCCCCCCCCCC
InChI
1S/C24H52NO6P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-29-22-24(26)23-31-32(27,28)30-21-19-25(2,3)4/h24,26H,5-23H2,1-4H3/t24-/m1/s1
InChI key
VLBPIWYTPAXCFJ-XMMPIXPASA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (840008P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 840008P
lipid type
phospholipids
phosphoglycerides
shipped in
dry ice
storage temp.
−20°C
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General description
Lyso-platelet activating factor (lyso-PAF) is the alkyl homolog of lysophosphatidylcholine.
Application
Lyso PAF (from Heart PC) (1-alkyl-2-hydroxy-sn-glycero-3-phosphocholine) has been used to study its inhibitory actions on alkyl-PAF-induced death in Swiss albino mice. It may be used as an acyl acceptor in the determination of lysophosphatidic acid (LPA) acyltransferase (LPAAT) activity.
Biochem/physiol Actions
Lyso-platelet activating factor (lyso-PAF) can stimulate inflammation in a murine model of pleurisy. It acts as a stable metabolite and a precursor of PAF. The turnover of lyso-PAF to PAF is expected to induce continued inflammation in target organs or tissues.
Packaging
5 mL Clear Glass Sealed Ampule (840008P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
G K Marathe et al.
Journal of lipid research, 42(9), 1430-1437 (2001-08-24)
Lysophosphatidylcholine is an abundant component of plasma and oxidized LDL that displays several biological activities, some of which may occur through the platelet-activating factor (PAF) receptor. We find that commercial lysophosphatidylcholine, its alkyl homolog (lyso-PAF), and PAF all induce inflammation
H Inoue et al.
Life sciences, 52(21), PL227-PL232 (1993-01-01)
The conversion of lyso-platelet activating factor (lyso-PAF) to PAF in cultured paranasal sinus mucosa obtained from normal human subjects was studied. The PAF concentration in the medium was determined after addition of lyso-PAF. PAF became detectable at 10 minutes after
Vyala Hanumanthareddy Chaithra et al.
Journal of lipid research, 59(11), 2063-2074 (2018-08-25)
Platelet-activating factor (PAF) is a potent inflammatory mediator that exerts its actions via the single PAF receptor (PAF-R). Cells that biosynthesize alkyl-PAF also make abundant amounts of the less potent PAF analogue acyl-PAF, which competes for PAF-R. Both PAF species
C Eberhardt et al.
The Journal of biological chemistry, 272(32), 20299-20305 (1997-08-08)
Lysophosphatidic acid (1-acyl-sn-glycero-3-phosphate (LPA)) is a phospholipid with diverse biological activities. The mediator serves as an intermediate in membrane phospholipid metabolism but is also produced in acute settings by activated platelets. LPA is converted to phosphatidic acid, itself a lipid
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