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Merck
CN

840012C

Avanti

Heart CA

Avanti Research™ - A Croda Brand

别名:

Cardiolipin (Heart, Bovine) (sodium salt)

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关于此项目

化学文摘社编号:
383907-10-6
MDL编号:
MFCD11974098
UNSPSC代码:
12352211
NACRES:
NA.25

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方案

>99% (TLC)

表单

liquid

包装

pkg of 1 × 2 mL (840012C-50mg)
pkg of 1 × 2.5 mL (840012C-25mg)
pkg of 1 × 4 mL (840012C-100mg)

制造商/商品名称

Avanti Research™ - A Croda Brand

浓度

10 mg/mL (840012C-25mg)
25 mg/mL (840012C-100mg)
25 mg/mL (840012C-50mg)

脂质类型

phosphoglycerides

运输

dry ice

储存温度

−20°C

SMILES字符串

[Na+].[Na+].[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCC\C=C/C\C=C/CCCCC)OCC(O)CO[P](=O)([O-])OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCC\C=C/C\C=C/CCCCC

InChI

1S/C81H142O17P2.2Na/c1-5-9-13-17-21-25-29-33-37-41-45-49-53-57-61-65-78(83)91-71-76(97-80(85)67-63-59-55-51-47-43-39-35-31-27-23-19-15-11-7-3)73-95-99(87,88)93-69-75(82)70-94-100(89,90)96-74-77(98-81(86)68-64-60-56-52-48-44-40-36-32-28-24-20-16-12-8-4)72-92-79(84)66-62-58-54-50-46-42-38-34-30-26-22-18-14-10-6-2;;/h21-28,33-40,75-77,82H,5-20,29-32,41-74H2,1-4H3,(H,87,88)(H,89,90);;/q;2*+1/p-2/b25-21-,26-22-,27-23-,28-24-,37-33-,38-34-,39-35-,40-36-;;/t76-,77-;;/m1../s1

InChI key

ZGSPNIOCEDOHGS-LBOJVHLDSA-L

相关类别

一般描述

Cardiolipin is a phospholipid found in the inner membrane of the mitochondria. It is synthesized from phosphatidylglycerol and cytidinediphosphate-diacylglycerol. It consists of two phosphatidyl residues, which are linked by a glycerol group.

应用

Heart CA has been used in the Mycobacterium lipid extraction and in β- Hexosaminidase release and calcium mobilization assays. It maybe used for liposome synthesis. It may also be used as a lipid standard for the in situ analysis and characterization of cardiolipins.

生化/生理作用

Cardiolipin is involved in maintaining the structure and function of the mitochondria. It also serves as a co-factor for stimulating mitochondrial enzymes and mediates mitochondrial apoptosis. Cardiolipin is associated with the oxidative phosphorylation system for the adenine triphosphate (ATP) synthesis in the inner membrane of the mitochondria. Deficiency of cardiolipin is associated with variation of mitochondrial membrane structure and function. It is also associated with Barth syndrome.

包装

5 mL Clear Glass Sealed Ampule (840012C-100mg)
5 mL Clear Glass Sealed Ampule (840012C-25mg)
5 mL Clear Glass Sealed Ampule (840012C-50mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

靶器官

Central nervous system, Liver,Kidney

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

does not flash

闪点(°C)

does not flash

法规信息

易制毒化学品（2类）
危险化学品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Cardiolipin, the heart of mitochondrial metabolism
Houtkooper R H and Vaz F M
Cellular and Molecular Life Sciences, 65(16), 2493-2506 (2008)
Direct MALDI-MS analysis of cardiolipin from rat organs sections
Wang Hay-Yan J, et al.
Journal of the American Society For Mass Spectrometry, 18(3), 567-577 (2007)
Cardiolipin stabilizes respiratory chain supercomplexes
Pfeiffer K, et al.
The Journal of Biological Chemistry, 278(52), 52873-52880 (2003)
Mycobacterial Lipids Induce Calcium Mobilization and Degranulation of Mast Cells
Torres-Atencio I, et al.
American Journal of Respiratory and Critical Care Medicine, 198(6), 813-816 (2018)
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification
Cole NB, et al.
Experimental Cell Research, 314(10), 2076-2089 (2008)
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