产品名称
12:0 PS, 1,2-dilauroyl-sn-glycero-3-phospho-L-serine (sodium salt), powder
SMILES string
[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O.[Na+]
InChI
1S/C30H58NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-28(32)38-23-26(24-39-42(36,37)40-25-27(31)30(34)35)41-29(33)22-20-18-16-14-12-10-8-6-4-2;/h26-27H,3-25,31H2,1-2H3,(H,34,35)(H,36,37);/q;+1/p-1/t26-,27+;/m1./s1
InChI key
QBSSGICBQYAHPS-OUPRKWGVSA-M
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (840038P-10mg), pkg of 1 × 200 mg (840038P-200mg), pkg of 1 × 25 mg (840038P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 840038P
lipid type
phospholipids
shipped in
dry ice
storage temp.
−20°C
General description
Phosphatidylserine (PS), an aminophospholipid is negatively charged and accounts for 2–10% of total cellular lipid. It is located in the membrane leaflets.
Application
12:0 PS may be used:
- in the preparation of large unilamellar vesicles (LUVs)
- as a standard to spike replicas of extracted lipid droplets and calibration curve generation for lipidomic analysis
- to study its effects on α-secretase activity
Biochem/physiol Actions
Phosphatidylserine (PS) plays a key role in protein kinase C pathways. It also helps in confining the intracellular proteins to membrane leaflets of cytosol.
Packaging
5 mL Amber Glass Screw Cap Vial (840038P-10mg)
5 mL Amber Glass Screw Cap Vial (840038P-200mg)
5 mL Amber Glass Screw Cap Vial (840038P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Kristof Schutters et al.
Apoptosis : an international journal on programmed cell death, 15(9), 1072-1082 (2010-05-05)
Cells are able to execute apoptosis by activating series of specific biochemical reactions. One of the most prominent characteristics of cell death is the externalization of phosphatidylserine (PS), which in healthy cells resides predominantly in the inner leaflet of the
Bao Fu Qiao et al.
The journal of physical chemistry. B, 117(17), 5073-5080 (2013-04-10)
Crystalline vesicles are promising nanomaterials due to their mechanical stability in various environments. To control their fabrication, it is essential to understand the effects of different experimental conditions on crystallization. Here we perform atomistic molecular dynamics simulations of anionic lipid
C Preston Moon et al.
Journal of molecular biology, 413(2), 484-494 (2011-09-06)
The free energy of unfolding of a membrane protein from lipids into water (ΔG(o)(w,l)) describes its equilibrium thermodynamic stability. Knowing this parameter gives insight into a membrane protein's sequence-structure-energy relationships. However, there are few measures of membrane protein stability because
Marcus O W Grimm et al.
International journal of molecular sciences, 14(3), 5879-5898 (2013-03-15)
Alzheimer's disease (AD) is characterized by extracellular accumulation of amyloid-β peptide (Aβ), generated by proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ generation is inhibited when the initial ectodomain shedding is caused by α-secretase, cleaving
Jung Yong Eum et al.
Journal of chromatography. A, 460849-460849 (2020-01-14)
Aging refers to the intracellular accumulation of reactive oxygen species that damages proteins, DNA, and lipids. As alterations in lipid metabolism may trigger metabolic disorders and the onset of metabolic diseases, changes in lipid profiles can be closely related to
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