产品名称
18:0-18:1 PS, 1-stearoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (sodium salt), powder
SMILES string
[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[Na+]
InChI
1S/C42H80NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h18,20,38-39H,3-17,19,21-37,43H2,1-2H3,(H,46,47)(H,48,49);/q;+1/p-1/b20-18-;/t38-,39+;/m1./s1
InChI key
ALPKKMIPHGSQRX-NJZWBUMZSA-M
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (840039P-10mg)
pkg of 2 × 100 mg (840039P-200mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 840039P
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
Application
18:0-18:1 PS（1-硬脂酰基-2-油酰基-sn-甘油-3-磷酸-L-丝氨酸（钠盐））：
- 已用于制备多层和单层脂质体
- 可用于制备用于脂质体结合测定的脂质体
- 可用于产生多层磷脂囊泡
Biochem/physiol Actions
磷脂酰丝氨酸（PS）在蛋白激酶C途径中起关键作用。
General description
18:0-18:1 PS（1-硬脂酰基-2-油酰基-sn-甘油-3-磷酸-L-丝氨酸）是以磷酸丝氨酸为骨架的修饰脂质的钠盐。
Packaging
5 mL透明玻璃密封安瓿（840039P-10mg）
5 mL透明玻璃密封安瓿（840039P-200mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Katarzyna Gajos et al.
Analytical and bioanalytical chemistry, 409(4), 1109-1119 (2016-11-09)
Among the various biomarkers that are used to diagnose or monitor disease, extracellular vesicles (EVs) represent one of the most promising targets in the development of new therapeutic strategies and the application of new diagnostic methods. The detection of circulating
Julie K Freed et al.
Endothelium : journal of endothelial cell research, 15(4), 225-230 (2008-07-30)
Previous studies have demonstrated that endothelial cells exposed to laminar shear stress are protected from apoptotic stimuli such as tumor necrosis factor (TNF)-alpha. The authors investigated the role of phosphatidylserine (PS) in this phenomenon. Western blot analysis of cleaved caspase
Kristof Schutters et al.
Apoptosis : an international journal on programmed cell death, 15(9), 1072-1082 (2010-05-05)
Cells are able to execute apoptosis by activating series of specific biochemical reactions. One of the most prominent characteristics of cell death is the externalization of phosphatidylserine (PS), which in healthy cells resides predominantly in the inner leaflet of the
Anne Jäkel et al.
Protein & cell, 1(2), 188-197 (2011-01-05)
The role of surfactant protein A (SP-A) in the recognition and clearance of apoptotic cells is well established, but to date, it is still not clear which surface molecules of apoptotic cells are involved in the process. Here we present
John M Harrington et al.
The Journal of biological chemistry, 289(36), 24811-24820 (2014-07-20)
Haptoglobin-related protein (Hpr) is a component of a minor subspecies of high density lipoproteins (HDL) that function in innate immunity. Here we show that assembly of Hpr into HDL is mediated by its retained N-terminal signal peptide, an unusual feature
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