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Merck
CN

840885C

Avanti

18:2 PA

Avanti Research™ - A Croda Brand

别名:

1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate (sodium salt); PA(18:2(9Z,12Z)/18:2(9Z,12Z))

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关于此项目

经验公式（希尔记法）:
C39H68O8PNa
化学文摘社编号:
322647-62-1
分子量:
718.92
MDL number:
MFCD00674304
UNSPSC Code:
51191904
NACRES:
NA.25

主要文件

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产品名称

18:2 PA, 1,2-dilinoleoyl-sn-glycero-3-phosphate (sodium salt), chloroform

SMILES string

[Na+].[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCC\C=C/C\C=C/CCCCC)O

InChI

1S/C39H69O8P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h11-14,17-20,37H,3-10,15-16,21-36H2,1-2H3,(H2,42,43,44);/q;+1/p-1/b13-11-,14-12-,19-17-,20-18-;/t37-;/m1./s1

InChI key

UMYNPOZOTCNQKB-DKSSBCNHSA-M

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (840885C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840885C

concentration

10 mg/mL (840885C-25mg)

lipid type

phospholipids

shipped in

dry ice

storage temp.

−20°C

Application

18:2 PA or 1,2-dilinoleoyl-sn-glycero-3-phosphate (sodium salt):
  • has been used as a supplement in mouse chow to see changes in small intestine gene expression
  • might be used in saposin-derived lipid nanoparticle (SapNP) formation
  • might be used in vacuolar mimic lipid (VML) proteoliposomes used for content-mixing assays

General description

Phosphatidic acid (PA) is a precursor of lysophosphatidic acid (LPA) and is present in leafy vegetables. 18:2 PA or 1,2-dilinoleoyl-sn-glycero-3-phosphate (sodium salt) is a sodium salt of glycerol phosphate, with substitution of two chains of linolenic acid at the sn-1 and sn-2 positions in the glycerol backbone.

Packaging

5 mL Clear Glass Sealed Ampule (840885C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

wgk

WGK 3

法规信息

危险化学品
易制毒化学品（2类）
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Mohamad Navab et al.
Journal of lipid research, 54(12), 3403-3418 (2013-10-03)
We recently reported that levels of unsaturated lysophosphatidic acid (LPA) in the small intestine significantly correlated with the extent of aortic atherosclerosis in LDL receptor-null (LDLR⁻/⁻) mice fed a Western diet (WD). Here we demonstrate that WD increases unsaturated (but
Hongki Song et al.
eLife, 9 (2020-01-22)
Yeast vacuole fusion requires R-SNARE, Q-SNAREs, and HOPS. A HOPS SM-family subunit binds the R- and Qa-SNAREs. We now report that HOPS binds each of the four SNAREs. HOPS catalyzes fusion when the Q-SNAREs are not pre-assembled, ushering them into
Ali Flayhan et al.
Structure (London, England : 1993), 26(2), 345-355 (2018-02-08)
Saposin-derived lipid nanoparticles (SapNPs) are a new alternative tool for membrane protein reconstitution. Here we demonstrate the potential and advantages of SapNPs. We show that SapA has the lowest lipid specificity for SapNP formation. These nanoparticles are modular and offer

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