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Merck
CN

841118C

Avanti

Egg Trans PE

Avanti Research™ - A Croda Brand

别名:

L-a-Phosphatidylethanolamine Transphosphatidylated (prepared from Egg PC)

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化学文摘社编号:
383907-63-9
MDL number:
MFCD00672608
UNSPSC Code:
12352211
NACRES:
NA.25

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产品名称

Egg Trans PE, L-α-phosphatidylethanolamine, transphosphatidylated (Egg, Chicken), chloroform

InChI

1S/C39H76NO8P/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-39(42)48-37(36-47-49(43,44)46-34-33-40)35-45-38(41)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h17-18,37H,3-16,19-36,40H2,1-2H3,(H,43,44)/b18-17-/t37-/m1/s1

InChI key

FHQVHHIBKUMWTI-OTMQOFQLSA-N

SMILES string

[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (841118C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 841118C

concentration

10 mg/mL (841118C-25mg)

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

Application

Egg Trans PE is suitable for use:
  • in the incubation of platelets for phospholipid enrichment and quantification by ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)
  • in the synthesis of isoketals-phosphatidylethanolamine (IsoK-PE)
  • in the preparation of phospholipid vesicles for factor X activation studies

Biochem/physiol Actions

Phosphatidylethanolamine (PE) along with other phospholipids forms the backbone of biological membranes. PE is known to regulate autophagy. The autophagic membranes possesses PE with high degree of unsaturation. Egg yolk PE has high radical scavenging activity owing to antioxidant potential.

General description

Phosphatidylethanolamine (PE) is a phospholipid found in all living organism. The egg yolk contains high levels of unsaturated PE which accounts to 83.10%. The phosphatidylethanolamine (PE) headgroup is a zwitterion, with a negatively charged phosphate group and positively charged free amine group.

Packaging

5 mL Clear Glass Sealed Ampule (841118C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

wgk

WGK 3

法规信息

危险化学品
易制毒化学品（2类）
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake
Bloem E, et al.
Journal of biological and chemical chronicles, 288(41), 29670-29679 (2013)
C Blake Sullivan et al.
Journal of lipid research, 51(5), 999-1009 (2009-12-08)
Levuglandins and their stereo- and regio-isomers (termed isolevuglandins or isoketals) are gamma-ketoaldehydes (IsoK) that rapidly react with lysines to form stable protein adducts. IsoK protein adduct levels increase in several pathological conditions including cardiovascular disease. IsoKs can induce ion channel
Isoketals form cytotoxic phosphatidylethanolamine adducts in cells
Sullivan CB, et al.
Journal of Lipid Research, 51(5), 999-1009 (2010)
The
The Membranes of Cells, 22(3) (2016)
Analytical characterization of the role of phospholipids in platelet adhesion and secretion
Koseoglu S, et al.
Analytical Chemistry, 87(1), 413-421 (2014)
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