产品名称
大豆Lyso PI, Avanti Research™ - A Croda Brand 850090P, powder
InChI
1S/C25H49O12P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)35-16-18(26)17-36-38(33,34)37-25-23(31)21(29)20(28)22(30)24(25)32;/h18,20-26,28-32H,2-17H2,1H3,(H,33,34);/q;+1/p-1/t18-,20-,21-,22+,23-,24-,25-;/m1./s1
InChI key
CPTWBHNULFRGAT-OGIGPNSJSA-M
SMILES string
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O)=O)(O)COC(CCCCCCCCCCCCCCC)=O.[Na+]
assay
>99% (LPI; may contain up to 10% of the 2-LPI isomer, TLC)
form
powder
packaging
pkg of 1 × 10 mg (850090P-10mg)
pkg of 1 × 5 mg (850090P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850090P
lipid type
phosphoglycerides
shipped in
dry ice
storage temp.
−20°C
Application
大豆Lyso PI或L-α-溶血磷脂酰肌醇（大豆）（钠盐）已用于：
- 在巨大的单层囊泡（GUVs）中，测量LysoPI对膜弯曲刚度的效应
- 作为外源性溶血磷脂来研究其对网格蛋白依赖性内吞作用的效应
- 作为测量两种重组小鼠GDE4和GDE7蛋白的甘油磷酸二酯磷酸二酯酶（GP-PDE）和溶血磷脂酶D活性的底物
Biochem/physiol Actions
溶血磷脂酰肌醇（LPI）是一种生物活性脂质，在许多生物学事件中均作为信号传导介质参与。它控制细胞生长、区分和运动。LPI与癌症细胞增殖等病理过程有关。
Packaging
5 mL棕色玻璃螺旋盖小瓶（850090P-10mg）
5 mL棕色玻璃螺旋盖小瓶（850090P-5mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
法规信息
动植物源性产品
此项目有
Noriyasu Ohshima et al.
The Journal of biological chemistry, 290(7), 4260-4271 (2014-12-22)
The known mammalian glycerophosphodiester phosphodiesterases (GP-PDEs) hydrolyze glycerophosphodiesters. In this study, two novel members of the mammalian GP-PDE family, GDE4 and GDE7, were isolated, and the molecular basis of mammalian GP-PDEs was further explored. The GDE4 and GDE7 sequences are
Syamsul A Arifin et al.
Metabolites, 6(1) (2016-01-20)
Metabolism is a chemical process used by cells to transform food-derived nutrients, such as proteins, carbohydrates and fats, into chemical and thermal energy. Whenever an alteration of this process occurs, the chemical balance within the cells is impaired and this
Ieva Ailte et al.
Traffic (Copenhagen, Denmark), 18(3), 176-191 (2017-01-10)
In this study, we have investigated how clathrin-dependent endocytosis is affected by exogenously added lysophospholipids (LPLs). Addition of LPLs with large head groups strongly inhibits transferrin (Tf) endocytosis in various cell lines, while LPLs with small head groups do not.
Alejandro Melero et al.
Current biology : CB, 28(12), 1950-1958 (2018-06-12)
Coat protein complex II (COPII) proteins form vesicles from the endoplasmic reticulum to export cargo molecules to the Golgi apparatus. Among the many proteins involved in this process, Sec12 is a key regulator, functioning as the guanosine diphosphate (GDP) exchange
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