产品名称
18:1 PI(3,4,5)P3, 1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′,5′-trisphosphate) (ammonium salt), powder
storage temp.
−20°C
InChI key
CTYBALUTLRWYAN-CJXCTDJBSA-N
SMILES string
[H][C@@](COP(O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP(O)([O-])=O)[C@@H](OP(O)([O-])=O)[C@H]1O)([O-])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+].[NH4+].[NH4+].[NH4+]
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 100 μg (with stopper and crimp cap (850156P-100ug)), pkg of 1 × 500 μg (with stopper and crimp cap (850156P-500ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand 850156P
lipid type
cardiolipins
phospholipids
shipped in
dry ice
General description
磷脂酰肌醇是一种结构性磷脂。磷脂酰肌醇磷酸（PIP）位于质膜中。
肌醇磷脂物质是膜结合的信号分子，它参与细胞生理学的几乎所有方面，包括细胞生长、代谢、增殖和存活。
Application
18：1 PI（3,4,5）P3 适合用于脂质原液的制备以形成混合胶束。它也已用于：
- 制备平面支撑脂质双层（SLB）
- 补充或丰富吞噬细胞膜
- 制备脂质体
Biochem/physiol Actions
与甘油磷脂相比，含磷酸肌醇的鞘脂可以以较低的水平诱导 ATPase。
Packaging
带塞子和压接盖的2 mL琥珀色精华瓶（850156P-100ug）
带塞子和压接盖的2 mL琥珀色精华瓶（850156P-500ug）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
Phosphatidylinositol Turnover and Receptors
Ramazzotti G, et al.
Archives of Biochemistry and Biophysics (2016)
Protein kinase Czeta exhibits constitutive phosphorylation and phosphatidylinositol-3, 4, 5-triphosphate-independent regulation
Tobias IS, et al.
The Biochemical Journal, 473(4), 509-523 (2016)
Achieving a graded immune response: BTK adopts a range of active/inactive conformations dictated by multiple interdomain contacts
Joseph RE, et al.
Structure, 25(10), 1481-1494 (2017)
K-Ras4B remains monomeric on membranes over a wide range of surface densities and lipid compositions
Chung JK, et al.
Biophysical Journal, 114(1), 137-145 (2018)
Dissociation of Rac1 (GDP)-RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3, 4, 5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP
Ugolev Y, et al.
The Journal of Biological Chemistry, 283(32), 22257-22271 (2008)
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