产品名称
18:0-20:4 PI(4,5)P2, 1-stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium salt), powder
form
powder
InChI key
GAIOWTITBYPFJE-WGJQOQIESA-N
SMILES string
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]
assay
>99% (TLC)
packaging
pkg of 1 × 100 μg (with stopper and crimp cap (850165P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850165P-500ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand 850165P
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
Application
18:0-20:4 PI（4，5）P2或1-硬脂酰基-2-花生四烯酰基-sn-甘油-3-磷酸-（1′-肌醇-4′，5′-双磷酸酯）（铵盐）已用于：
- 低温电子显微镜检查（cryo-EM）网格制备
- 宿主1-O-1-(Z)-十八碳烯基-2-花生四烯酰基-sn-甘油-3-磷酸胆碱（plasmenyl-SAPC）小单层囊泡中（SUVs），在H2O2的存在下激活cyt c缩醛磷脂酶活性
- 研究酰基链类型是否影响磷脂酰肌醇4，5-二磷酸（PIP2）簇的形成
General description
尽管PI(4,5)P2是细胞膜的次要成分，但它作为许多重要信号转导蛋白的底物发挥着重要作用。PI(4,5)P2是IP3/DAG途径中的中间体，在该途径中，它被磷脂酶C水解，释放第二信使，即肌醇1,4,5-三磷酸（IP3）和二酰基甘油（DAG）。PI(4,5)P2也是PI 3-激酶的底物，可被磷酸化为PI(3,4,5)P3，后者是下游信号转导成分（如蛋白激酶AKT）的激活剂。
磷脂酰肌醇4,5-二磷酸（PIP2）是一种带负电荷的磷脂，在质膜中含量丰富。
Packaging
带塞子和压接盖的2 mL棕色血清瓶（850165P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（850165P-500ug）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Christopher M Jenkins et al.
The Journal of biological chemistry, 293(22), 8693-8709 (2018-03-14)
Plasmalogens are phospholipids critical for cell function and signaling that contain a vinyl ether linkage at the sn-1 position and are highly enriched in arachidonic acid (AA) at the sn-2 position. However, the enzyme(s) responsible for the cleavage of the
Peter Y Mercredi et al.
Journal of molecular biology, 428(8), 1637-1655 (2016-03-20)
Assembly of HIV-1 particles is initiated by the trafficking of viral Gag polyproteins from the cytoplasm to the plasma membrane, where they co-localize and bud to form immature particles. Membrane targeting is mediated by the N-terminally myristoylated matrix (MA) domain
Tao Liang et al.
The Journal of biological chemistry, 289(9), 6028-6040 (2014-01-17)
In β-cells, syntaxin (Syn)-1A interacts with SUR1 to inhibit ATP-sensitive potassium channels (KATP channels). PIP2 binds the Kir6.2 subunit to open KATP channels. PIP2 also modifies Syn-1A clustering in plasma membrane (PM) that may alter Syn-1A actions on PM proteins
George Khelashvili et al.
Biochemistry, 51(39), 7685-7698 (2012-09-07)
Syntaxin (STX) is a N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein that binds to the plasma membrane and regulates ion channels and neurotransmitter transporters. Experiments have established the involvement of the N-terminal segment of STX in direct protein-protein interactions and
Qinrui Wang et al.
Structure (London, England : 1993), 28(2), 169-184 (2019-12-07)
Polycystin-2 (PC2) is a transient receptor potential (TRP) channel present in ciliary membranes of the kidney. PC2 shares a transmembrane fold with other TRP channels, in addition to an extracellular domain found in TRPP and TRPML channels. Using molecular dynamics
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