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Merck
CN

850187P

Avanti

08:0 PI(3)P

Avanti Research™ - A Croda Brand

别名:

1,2-二辛酰基-sn-甘油-3-磷酸-(1′-肌醇-3′-磷酸) (铵盐); PIP[3′](8:0/8:0)

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关于此项目

经验公式（希尔记法）:
C25H54N2O16P2
化学文摘社编号:
299216-98-1
分子量:
700.65
UNSPSC Code:
51191904
NACRES:
NA.25

主要文件

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产品名称

08:0 PI(3)P, 1,2-dioctanoyl-sn-glycero-3-(phosphoinositol-3-phosphate) (ammonium salt), powder

InChI

1S/C25H48O16P2.2H3N/c1-3-5-7-9-11-13-18(26)37-15-17(39-19(27)14-12-10-8-6-4-2)16-38-43(35,36)41-25-22(30)20(28)21(29)24(23(25)31)40-42(32,33)34;;/h17,20-25,28-31H,3-16H2,1-2H3,(H,35,36)(H2,32,33,34);2*1H3/t17-,20+,21+,22-,23-,24-,25+;;/m1../s1

InChI key

IHRPLAYZBAFIEF-ACHOKTOGSA-N

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OP([O-])(O)=O)[C@H]1O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+]

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 μg (with stopper and crimp cap (850187P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850187P-500ug))

manufacturer/tradename

Avanti Research™ - A Croda Brand 850187P

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

相关类别

Application

08:0 PI(3)P 已用于制备用于蛋白质重组和结构研究的模型膜。

Biochem/physiol Actions

3-单磷酸磷脂酰肌醇（PI3P）参与囊泡转运过程。它还在内吞作用中起关键作用。

General description

3-单磷酸磷脂酰肌醇（PI3P）是一种脂质，在真核细胞中含量丰富。 它在哺乳动物细胞中的含量较低。

Packaging

带塞子和压接盖的2 mL棕色血清瓶（850187P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（850187P-500ug）

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

No data available

flash_point_c

No data available

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Lina Tawk et al.
Eukaryotic cell, 9(10), 1519-1530 (2010-08-17)
Phosphoinositides are important regulators of diverse cellular functions, and phosphatidylinositol 3-monophosphate (PI3P) is a key element in vesicular trafficking processes. During its intraerythrocytic development, the malaria parasite Plasmodium falciparum establishes a sophisticated but poorly characterized protein and lipid trafficking system.
Structural and functional studies of membrane remodeling machines
Methods in Cell Biology, 128, 165-200 (2015)
Etienne Morel et al.
Nature communications, 4, 2250-2250 (2013-08-03)
Defects in endosomal sorting have been implicated in Alzheimer's disease. Endosomal traffic is largely controlled by phosphatidylinositol-3-phosphate, a phosphoinositide synthesized primarily by lipid kinase Vps34. Here we show that phosphatidylinositol-3-phosphate is selectively deficient in brain tissue from humans with Alzheimer's

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