850312P
Avanti
DOCPe
Avanti Research™ - A Croda Brand
别名:
2-((2,3-bis(oleoyloxy)propyl)dimethylammonio)ethyl ethyl phosphate
产品名称
DOCPe, Avanti Research™ - A Croda Brand 850312P, powder
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 200 mg (850312P-200mg)
pkg of 1 × 25 mg (850312P-25mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 850312P
脂质类型
phospholipids
cardiolipins
运输
dry ice
储存温度
−20°C
SMILES字符串
[H]C(C[N+](C)(CCOP([O-])(OCC)=O)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O
InChI
1S/C45H86NO8P/c1-6-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-44(47)51-42-43(41-46(4,5)39-40-53-55(49,50)52-8-3)54-45(48)38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-7-2/h21-24,43H,6-20,25-42H2,1-5H3/b23-21-,24-22-
InChI key
WDTDXEZJIUAULM-SXAUZNKPSA-N
一般描述
2-((2,3-bis(oleoyloxy)propyl)dimethylammonio)ethyl ethylphosphate (DOCPe) is a neutrally charged lipid.
Inverse-phosphocholine lipids, a remix of a common phospholipid, contain headgroups with an inverted charge orientation relative to phosphocholine (PC) lipids. The iPC lipid headgroup has a quaternary amine adjacent to the bilayer interface and a phosphate that extends into the aqueous phase. Therefore iPC lipids afford a unique opportunity to investigate the biophysical and bioactivity-related ramifications of a charge inversion at the bilayer surface.
应用
DOCPe is suitable for liposomes preparation.
包装
20 mL Clear Glass Screw Cap Vial (850312P-200mg)
5 mL Clear Glass Sealed Ampule (850312P-25mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Charge and Coordination Directed Liposome Fusion onto SiO2 and TiO2 Nanoparticles
Wang X, et al.
Langmuir, 35(5), 1672-1681 (2018)
Emily K Perttu et al.
Journal of the American Chemical Society, 134(10), 4485-4488 (2012-03-01)
Zwitterionic inverse-phosphocholine (iPC) lipids contain headgroups with an inverted charge orientation relative to phosphocholine (PC) lipids. The iPC lipid headgroup has a quaternary amine adjacent to the bilayer interface and a phosphate that extends into the aqueous phase. Neutral iPC
Yibo Liu et al.
Langmuir : the ACS journal of surfaces and colloids, 34(32), 9337-9348 (2018-03-13)
Phospholipids are a major component of the cell membrane. In most natural phospholipids, the phosphate acts as a bridge, connecting the other portion of the polar headgroup with the hydrophobic tails. Such bridging phosphate is chemically quite inert. Synthetic lipids
Feng Wang et al.
Journal of the American Chemical Society, 137(36), 11736-11742 (2015-08-25)
Zwitterionic phosphocholine (PC) lipids are highly biocompatible, representing a major component of the cell membrane. A simple mixing of PC liposomes and silica (SiO2) surface results in liposome fusion with the surface and formation of supported lipid bilayers. However, the
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