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关于此项目
经验公式（希尔记法）:
C24H48NO8P
化学文摘社编号:
分子量:
509.61
MDL number:
NACRES:
NA.25
UNSPSC Code:
51191904
产品名称
08:0 PC, 1,2-dioctanoyl-sn-glycero-3-phosphocholine, chloroform
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 2.5 mL (850315C-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850315C
concentration
10 mg/mL (850315C-25mg)
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
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General description
Phosphatidylcholine (PC), a major phospholipid is mostly found in the membrane of mammals. The headgroup of this bilayer-forming lipid carries a positively and negatively charged quaternary amine and a phosphate respectively. 08:0 PC (1,2-dioctanoyl-sn-glycero-3-phosphocholine) is a saturated synthetic short-chain phospholipid.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.
Application
08:0 PC (1,2-dioctanoyl-sn-glycero-3-phosphocholine) has been used to form a lipid film to study its effect on P-glycoprotein′s (P-gp′s) activity/to compare its effect with TWEEN®80. It may be used to study its effect on the nicotinamide adenine dinucleotide (NADH): n-decylubiquinone (DBQ) activity of complex I. It may also be used as a bicellar model to study their phase behavior.
Packaging
5 mL Clear Glass Sealed Ampule (850315C-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TWEEN is a registered trademark of Croda International PLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system, Liver,Kidney
wgk
WGK 3
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
易制毒化学品（2类）
危险化学品
此项目有
Phase behavior of a binary lipid system containing long- and short-chain phosphatidylcholines
Sun HY, et al.
Royal Society of Chemistry Advances, 7(10), 5715-5724 null
Lipid-Protein Interactions in Membranes
The Membranes of Cells, 291-334 null
Manuel Weinheimer et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 108, 13-22 (2016-09-04)
The efflux transporter P-glycoprotein (P-gp) significantly modulates drug transport across the intestinal mucosa, strongly reducing the systemic absorption of various active pharmaceutical ingredients. P-gp inhibitors could serve as helpful tools to enhance the oral bioavailability of those substances. As a
Stefan Dröse et al.
Biochimica et biophysica acta, 1556(1), 65-72 (2002-09-28)
NADH:ubiquinone oxidoreductase (complex I) is the largest multiprotein complex of the mitochondrial respiratory chain. His-tagged complex I purified from the strictly aerobic yeast Yarrowia lipolytica exhibited electron transfer rates from NADH to n-decylubiquinone of less than 2% when compared to
Teruhiko Baba et al.
Chemistry and physics of lipids, 227, 104870-104870 (2020-01-10)
Interfacial properties and membrane protein solubilization activity of a series of partially fluorinated octyl-phosphocholine (PC) surfactants were investigated from the viewpoint of the fluorination degree of the hydrophobic chain. The critical micelle concentration (CMC), surface tension lowering activity, molecular occupied
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