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经验公式（希尔记法）:
C44H84NO8P
化学文摘社编号:
分子量:
786.11
MDL number:
UNSPSC Code:
51191904
NACRES:
NA.25
产品名称
18:1 (Δ6-Cis) PC, 1,2-dipetroselenoyl-sn-glycero-3-phosphocholine, powder
InChI key
KLJBLQFSKZACGJ-MMKOEKFTSA-N
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCC/C=C\CCCCCCCCCCC)=O)COC(CCCC/C=C\CCCCCCCCCCC)=O)=O
assay
>99% (TLC)
form
powder
packaging
pkg of 2 × 100 mg (850374P-200mg)
pkg of 1 × 25 mg (850374P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850374P
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
Application
18:1 (Δ6-Cis) PC (1,2-dipetroselenoyl-sn-glycero-3-phosphocholine) may be used:
- to generate sn-1 C18:1(Δ6-cis)- lysophosphatidylcholine (LPC) and sn-1 C18:1(Δ9-cis)-LPC standards for structural characterization of lysophosphatidylcholine (LPC) species by tandem electrospray ionization-linear ion trap-mass spectrometry (ESI-LIT-MS)
- to study the effect on α-secretase activity in SH-SY5Y membranes
- in liposome to study the effect of its acyl chain length and bond saturation on pore formation
Biochem/physiol Actions
Phosphatidylcholines (PCs) help to reduce the level of blood lipid and cholesterol.
General description
18:1 (Δ6-Cis) PC (1,2-dipetroselenoyl-sn-glycero-3-phosphocholine), a lipid derivative is made up of a phosphocholine backbone. It has two18 carbon fatty acid chains, each having one cis double bond at the 6th carbon.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.
Packaging
5 mL Clear Glass Sealed Ampule (850374P-200mg)
5 mL Clear Glass Sealed Ampule (850374P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Koldo Morante et al.
The Journal of biological chemistry, 290(17), 10850-10861 (2015-03-12)
The physicochemical landscape of the bilayer modulates membrane protein function. Actinoporins are a family of potent hemolytic proteins from sea anemones acting at the membrane level. This family of cytolysins preferentially binds to target membranes containing sphingomyelin, where they form
Felipe Gazos-Lopes et al.
PLoS neglected tropical diseases, 8(8), e3077-e3077 (2014-08-08)
Trypanosoma cruzi is the causative agent of the life-threatening Chagas disease, in which increased platelet aggregation related to myocarditis is observed. Platelet-activating factor (PAF) is a potent intercellular lipid mediator and second messenger that exerts its activity through a PAF-specific
Marcus O W Grimm et al.
International journal of molecular sciences, 14(3), 5879-5898 (2013-03-15)
Alzheimer's disease (AD) is characterized by extracellular accumulation of amyloid-β peptide (Aβ), generated by proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ generation is inhibited when the initial ectodomain shedding is caused by α-secretase, cleaving
Miao-Miao Zhou et al.
Lipids in health and disease, 15(1), 135-135 (2016-08-26)
Phosphatidylcholine (PC), the major source of dietary choline, has been demonstrated to improve the capability of learning and memory in rodent and the amelioration of long-chain n-3 polyunsaturated fatty acids (PUFA) on anti-aging and anti-oxidation is widely known as well.
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