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经验公式（希尔记法）:
C52H100NO8P
化学文摘社编号:
分子量:
898.33
MDL number:
UNSPSC Code:
51191904
NACRES:
NA.25
产品名称
PC 22:1（顺式）, 1,2-dierucoyl-sn-glycero-3-phosphocholine, powder
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCC/C=C\CCCCCCCC)=O)=O
InChI
1S/C52H100NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-40-42-44-51(54)58-48-50(49-60-62(56,57)59-47-46-53(3,4)5)61-52(55)45-43-41-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h20-23,50H,6-19,24-49H2,1-5H3/b22-20+,23-21+/t50-/m1/s1
InChI key
SDEURMLKLAEUAY-QVOKQPLLSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 25 mg (850398P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850398P
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
Application
22:1 (Cis) PC has been used as in the preparation of model membrane mimicking T-cell (LM3). It is suitable for use to study about lipid dynamics and also to investigate the effect of cholesterol on it.
Biochem/physiol Actions
22:1 (Cis) PC/1,2-dierucoyl-sn-glycero-3-phosphocholine (DEPC) is a longer lipid. It is 7 Å thicker, when compared to 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).
General description
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.
Packaging
5 mL Clear Glass Sealed Ampule (850398P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Dynamic assessment of bilayer thickness by varying phospholipid and hydraphile synthetic channel chain lengths
Weber ME, et al.
Journal of the American Chemical Society, 127(2), 636-642 (2005)
How phospholipid-cholesterol interactions modulate lipid lateral diffusion, as revealed by fluorescence correlation spectroscopy
Kahya N and Schwille P
Journal of Fluorescence, 16(5), 671-678 (2006)
HIV fusion peptide penetrates, disorders, and softens T-cell membrane mimics
Tristram NS, et al.
Journal of Molecular Biology, 402(1), 139-153 (2010)
Dependence of M13 major coat protein oligomerization and lateral segregation on bilayer composition
Fernandes F, et al.
Biophysical Journal, 85(4), 2430-2441 (2003)
Gareth R Tibbs et al.
The Journal of pharmacology and experimental therapeutics, 345(3), 363-373 (2013-04-04)
Chronic pain after peripheral nerve injury is associated with afferent hyperexcitability and upregulation of hyperpolarization-activated, cyclic nucleotide-regulated (HCN)-mediated IH pacemaker currents in sensory neurons. HCN channels thus constitute an attractive target for treating chronic pain. HCN channels are ubiquitously expressed;
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