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Merck
CN

850446C

Avanti

14:0-18:0 PC

Avanti Research™ - A Croda Brand

别名:

1-tetradecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine; MSPC; PC(14:0/18:0)

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关于此项目

经验公式（希尔记法）:
C40H80NO8P
化学文摘社编号:
76343-22-1
分子量:
734.04
MDL number:
MFCD00674323
UNSPSC Code:
51191904
NACRES:
NA.25

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产品名称

14:0-18:0 PC, 1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine, chloroform

SMILES string

[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCC)OCC[N+](C)(C)C

InChI

1S/C40H80NO8P/c1-6-8-10-12-14-16-18-19-20-21-23-25-27-29-31-33-40(43)49-38(37-48-50(44,45)47-35-34-41(3,4)5)36-46-39(42)32-30-28-26-24-22-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1

InChI key

TYAQXZHDAGZOEO-KXQOOQHDSA-N

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (850446C-25mg)
pkg of 2 × 4 mL (850446C-200mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850446C

concentration

10 mg/mL (850446C-25mg)
25 mg/mL (850446C-200mg)

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

Application

14:0-18:0 PC (1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine) may be used:
  • in lipid bilayers to study its miscibility with d-erythro-N-palmitoyl-sphingomyelin (16:0-SM) using differential scanning calorimetry (DSC)
  • as an asymmetrical lipid in liposomes to study the impact of bilayer area and lipid geometry on the design of liposomes as liposomal solubilizing agents
  • to prepare a low temperature-sensitive liposome encapsulating thrombolytics to assess thrombolytic activity following hyperthermia

Biochem/physiol Actions

Phosphatidylcholine (PC) can form a hydrophobic surface in the mucus by acting as a surfactant to inhibit the penetrance of bacteria.

General description

Phosphatidylcholine (PC) is one of the most important constituent of colon′s mucosal layer. 14:0-18:0 PC (1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine) is an asymmetrical lipid.

Packaging

5 mL Clear Glass Sealed Ampule (850446C-200mg)
5 mL Clear Glass Sealed Ampule (850446C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Liver,Kidney, Respiratory system

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Inflammatory Bowel Disease
Integrative Medicine, 501-516 (2018)
Vishal Saxena et al.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 31(1), 67-73 (2015-03-15)
Clinical efficacy of thrombolytic drugs is limited by lack of specific delivery and requires large therapeutic doses which increase toxicity. Encapsulating these drugs in temperature-sensitive liposomes and applying hyperthermia to deliver thrombolytic agents locally to thrombus might theoretically favourably alter
M Habib Ali et al.
International journal of pharmaceutics, 453(1), 225-232 (2012-07-07)
Liposomes are well recognised for their ability to improve the delivery of a range of drugs. More commonly they are applied for the delivery of water-soluble drugs, but given their structural attributes, they can also be employed as solubilising agents
Bohdana Térová et al.
Biochimica et biophysica acta, 1667(2), 182-189 (2004-12-08)
In this study we have used differential scanning calorimetry (DSC) to study the miscibility of different saturated phosphatidylcholines (PCs) with D-erythro-N-palmitoyl-sphingomyelin (16:0-SM). Information about the miscibility was obtained by observing the thermotropic phase behavior of binary mixtures of saturated PCs
Van Du Nguyen et al.
ACS applied materials & interfaces, 12(9), 10130-10141 (2020-02-12)
Although great efforts have been undertaken to develop a nanoparticle-based drug delivery system (DDS) for the treatment of solid tumors, the therapeutic outcomes are still limited. Immune cells, which possess an intrinsic ability to phagocytose nanoparticles and are recruited by
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