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关于此项目
经验公式（希尔记法）:
C40H80NO8P
化学文摘社编号:
分子量:
734.04
MDL number:
UNSPSC Code:
51191904
NACRES:
NA.25
产品名称
14:0-18:0 PC, 1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine, powder
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O)=O
InChI
1S/C40H80NO8P/c1-6-8-10-12-14-16-18-19-20-21-23-25-27-29-31-33-40(43)49-38(37-48-50(44,45)47-35-34-41(3,4)5)36-46-39(42)32-30-28-26-24-22-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1
InChI key
TYAQXZHDAGZOEO-KXQOOQHDSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 200 mg (850446P-200mg)
pkg of 1 × 25 mg (850446P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850446P
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
Application
14:0-18:0 PC（1-肉豆蔻酰基-2-硬脂酰基-sn-甘油-3-磷酸胆碱）可用于：
- 脂质双层，采用差示扫描量热法（DSC）研究其与d-赤型-N-棕榈酰基-鞘磷脂（16:0-SM）的混溶性，
- 作为脂质体中的不对称脂质成分，研究双层面积和脂质几何形状的影响，并作为脂质体增溶剂
- 制备用于溶栓研究的低温敏感脂质体
Biochem/physiol Actions
磷脂酰胆碱（PC）通过充当表面活性剂在粘液中形成疏水表面，从而抑制细菌的渗透。
General description
磷脂酰胆碱（PC）是结肠′粘膜层最重要的成分之一。14:0-18:0 PC（1-肉豆蔻酰基-2-硬脂酰基-sn-甘油-3-磷酸胆碱）是具有长烷基侧链的不对称脂质。
Packaging
5 mL棕色玻璃螺旋盖小瓶（850446P-200mg）
5 mL棕色玻璃螺旋盖小瓶（850446P-25mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Inflammatory Bowel Disease
Integrative Medicine, 501-516 (2018)
M Habib Ali et al.
International journal of pharmaceutics, 453(1), 225-232 (2012-07-07)
Liposomes are well recognised for their ability to improve the delivery of a range of drugs. More commonly they are applied for the delivery of water-soluble drugs, but given their structural attributes, they can also be employed as solubilising agents
Van Du Nguyen et al.
ACS applied materials & interfaces, 12(9), 10130-10141 (2020-02-12)
Although great efforts have been undertaken to develop a nanoparticle-based drug delivery system (DDS) for the treatment of solid tumors, the therapeutic outcomes are still limited. Immune cells, which possess an intrinsic ability to phagocytose nanoparticles and are recruited by
Bohdana Térová et al.
Biochimica et biophysica acta, 1667(2), 182-189 (2004-12-08)
In this study we have used differential scanning calorimetry (DSC) to study the miscibility of different saturated phosphatidylcholines (PCs) with D-erythro-N-palmitoyl-sphingomyelin (16:0-SM). Information about the miscibility was obtained by observing the thermotropic phase behavior of binary mixtures of saturated PCs
Vishal Saxena et al.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 31(1), 67-73 (2015-03-15)
Clinical efficacy of thrombolytic drugs is limited by lack of specific delivery and requires large therapeutic doses which increase toxicity. Encapsulating these drugs in temperature-sensitive liposomes and applying hyperthermia to deliver thrombolytic agents locally to thrombus might theoretically favourably alter
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