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Merck
CN

850459C

Avanti

16:0-20:4 PC

Avanti Research™ - A Croda Brand

别名:

1-hexadecanoyl-2--(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine; PAPC; PC(16:0/20:4(5Z,8Z,11Z,14Z))

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关于此项目

经验公式（希尔记法）:
C44H80NO8P
化学文摘社编号:
35418-58-7
分子量:
782.08
MDL编号:
MFCD00171671
UNSPSC代码:
51191904
NACRES:
NA.25

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描述

1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine, chloroform

方案

>99% (TLC)

表单

liquid

包装

pkg of 1 × 2.5 mL (850459C-25mg)
pkg of 2 × 4 mL (850459C-200mg)

制造商/商品名称

Avanti Research™ - A Croda Brand

浓度

10 mg/mL (850459C-25mg)
25 mg/mL (850459C-200mg)

脂质类型

cardiolipins
phospholipids

运输

dry ice

储存温度

−20°C

SMILES字符串

[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC)OCC[N+](C)(C)C

InChI

1S/C44H80NO8P/c1-6-8-10-12-14-16-18-20-21-22-23-25-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-24-19-17-15-13-11-9-7-2/h14,16,20-21,23,25,28,30,42H,6-13,15,17-19,22,24,26-27,29,31-41H2,1-5H3/b16-14-,21-20-,25-23-,30-28-/t42-/m1/s1

InChI key

PUDHBQQGURLBGJ-IVFHWKNFSA-N

相关类别

一般描述

Phosphatidylcholine (PC) is one of the major glycerophospholipids of the eukaryotic membranes. PC is zwitterionic. PC is synthesized via two pathways in higher eukaryotes like the triple methylation of phosphatidylethanolamine and the cytidine diphosphate (CDP)-choline pathway.

应用

16:0-20:4 PC is suitable for use:
  • in the preparation of auto-oxidised phospholipid for electrospray ionisation mass spectroscopic (ESI-MS) analysis
  • in liposome preparation for the treatment of organoid
  • as antigen in enzyme linked immunosorbent assay (ELISA) for the detection of autoantibodies to phospholipids

生化/生理作用

Phosphatidylcholine (PC) is essential for maintaining the structure and functions of the membrane. PC is the substrate for sphingomyelin synthesis. PC is the precursor for various second messenger like phosphatidic acid, lysophosphatidic acid, diacylglycerol. PC is the dominant phospholipid present in cancer and neo-neoplastic tissues. Level of 16:0-20:4 PC is less in multiple myeloma cells than in normal plasma cells.

包装

5 mL Clear Glass Sealed Ampule (850459C-200mg)
5 mL Clear Glass Sealed Ampule (850459C-25mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

靶器官

Central nervous system, Liver,Kidney

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

does not flash

闪点(°C)

does not flash

法规信息

易制毒化学品（2类）
危险化学品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Autoantibodies to oxidized low density lipoprotein in relation with coronary artery disease
Soto Y, et al.
Human Antibodies, 18(3), 109-117 (2009)
Mohamad Navab et al.
Circulation, 109(25), 3215-3220 (2004-06-16)
These studies were designed to determine the mechanism of action of an oral apolipoprotein (apo) A-I mimetic peptide, D-4F, which previously was shown to dramatically reduce atherosclerosis in mice. Twenty minutes after 500 microg of D-4F was given orally to
Identification of oxidized phospholipids by electrospray ionization mass spectrometry and LC-MS using a QQLIT instrument
Spickett CM, et al.
Free Radical Res. Commun., 51(12), 2133-2149 (2011)
Phospholipid remodeling and cholesterol availability regulate intestinal stemness and tumorigenesis
Wang B, et al.
Cell Stem Cell, 22(2), 206-220 (2018)
Decreased level of phosphatidylcholine (16: 0/20: 4) in multiple myeloma cells compared to plasma cells: a single-cell MALDI-IMS approach
Hossen MD, et al.
Analytical and Bioanalytical Chemistry, 407(18), 5273-5280 (2015)
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