产品名称
Facade™-TEM, 3α,7α,12α-tri-((O-β-D-maltopyranosyl)ethyloxy)-cholane, powder
方案
>99% (TLC)
表单
powder
分子量
1483.59 g/mol
包装
pkg of 1 × 25 mg (850537P-25mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 850537P
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@@]12[C@]([C@](CC[C@@H](OCCO[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@@H](CO)O3)C5)(C)[C@]5([H])C[C@H]2OCCO[C@@H]6[C@@H](O)[C@H](O)[C@@H](O[C@H]7[C@@H](O)[C@H](O)[C@@H](O)[C@H](CO)O7)[C@H](CO)O6)([H])C[C@H](OCCO[C@
一般描述
Facade™TEM/FA-4 (3α,7α,12α-tri-((O-β-D-maltopyranosyl)ethyloxy)-cholane) is a sterol-based/sugar-based facial amphiphile. It carries three sugar attachments on the steroid backbone.
生化/生理作用
Facade™TEM/FA-4 (3α,7α,12α-tri-((O-β-D-maltopyranosyl)ethyloxy)-cholane) can be used in the preparation of micelles. It may also be used in the stabilization and crystallization of membrane proteins. FA-4 is not effective as a cystic fibrosis transmembrane conductance regulator (CFTR) solubilizer.
包装
5 mL Amber Glass Screw Cap Vial (850537P-25mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Facade is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
法规信息
涉药品监管产品
Designing facial amphiphiles for the stabilization of integral membrane proteins.
Qinghai Zhang et al.
Angewandte Chemie (International ed. in English), 46(37), 7023-7025 (2007-08-11)
Sung Chang Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(13), E1203-E1211 (2013-03-13)
Amphiphile selection is a critical step for structural studies of membrane proteins (MPs). We have developed a family of steroid-based facial amphiphiles (FAs) that are structurally distinct from conventional detergents and previously developed FAs. The unique FAs stabilize MPs and
Ellen Hildebrandt et al.
Biochimica et biophysica acta, 1838(11), 2825-2837 (2014-07-30)
Structural knowledge of the cystic fibrosis transmembrane conductance regulator (CFTR) requires developing methods to purify and stabilize this aggregation-prone membrane protein above 1mg/ml. Starting with green fluorescent protein- and epitope-tagged human CFTR produced in mammalian cells known to properly fold
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