产品名称
MSDH, Avanti Research™ - A Croda Brand 850546P, powder
InChI
1S/C16H34N2O2.ClH/c1-3-4-5-6-7-8-9-10-11-12-13-18-16(19)15(17)14-20-2;/h15H,3-14,17H2,1-2H3,(H,18,19);1H/t15-;/m0./s1
InChI key
KEFSFBIMLKNBML-RSAXXLAASA-N
SMILES string
[NH3+][C@@H](COC)C(NCCCCCCCCCCCC)=O.[Cl-]
assay
>99% (TLC)
form
powder
mol wt
322.91 g/mol
packaging
pkg of 1 × 25 mg (850546P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850546P
shipped in
dry ice
storage temp.
−20°C
General description
O-methyl-serine-dodecylamide hydrochloride (MSDH) is a synthetic lysosomotropic detergent.
Application
MSDH is suitable is suitable to induce lysosomal membrane destabilization to investigate the mechanistic basis for Bax/Bak-mediated autophagic cell death.
Biochem/physiol Actions
O-methyl-serine-dodecylamide hydrochloride (MSDH) stimulates cell death. After apoptosis, it may activate procaspase 3-like proteases and cause partial lysosomal rupture.
Packaging
5 mL Amber Glass Screw Cap Vial (850546P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
Induction of cell death by the lysosomotropic detergent MSDH
Li W, et al.
Febs Letters, 470(1), 35-39 (2000)
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis
Fucho R, et al.
Journal of Hepatology, 61(5), 1126-1134 (2014)
Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak
Karch J, et al.
eLife, 6, e30543-e30543 (2017)
Methylmercury and H2O2 provoke lysosomal damage in human astrocytoma D384 cells followed by apoptosis
Dare E, et al.
Free radical biology & medicine, 30(12), 1347-1356 (2001)
Ana M Villamil Giraldo et al.
Langmuir : the ACS journal of surfaces and colloids, 32(50), 13566-13575 (2016-12-13)
Lysosomotropic detergents (LDs) selectively rupture lysosomal membranes through mechanisms that have yet to be characterized. A consensus view, currently, holds that LDs, which are weakly basic, diffuse across cellular membranes as monomers in an uncharged state, and via protonation in
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