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Merck
CN

855475P

Avanti

12:0 Lyso PC

Avanti Research™ - A Croda Brand

别名:

1-十二烷酰基-sn-甘油-3-磷酸胆碱；PC(12:0/0:0)

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关于此项目

经验公式（希尔记法）:
C20H42NO7P
化学文摘社编号:
20559-18-6
分子量:
439.52
MDL number:
MFCD00133434
UNSPSC Code:
51191904
NACRES:
NA.25

主要文件

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产品名称

12:0 Lyso PC, 1-lauroyl-2-hydroxy-sn-glycero-3-phosphocholine, powder

SMILES string

O[C@](COP([O-])(OCC[N+](C)(C)C)=O)([H])COC(CCCCCCCCCCC)=O

InChI

1S/C20H42NO7P/c1-5-6-7-8-9-10-11-12-13-14-20(23)26-17-19(22)18-28-29(24,25)27-16-15-21(2,3)4/h19,22H,5-18H2,1-4H3/t19-/m1/s1

InChI key

BWKILASWCLJPBO-LJQANCHMSA-N

assay

>99% (LPC; may contain up to 10% of the 2-LPC isomer, TLC)

form

powder

packaging

pkg of 1 × 200 mg (855475P-200mg)
pkg of 1 × 25 mg (855475P-25mg)
pkg of 1 × 500 mg (855475P-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 855475P

shipped in

dry ice

storage temp.

−20°C

相关类别

Application

12:0 Lyso PC已用于研究其神经形成活性和外源性脂质的应用。

Biochem/physiol Actions

溶血磷脂酰胆碱（LPC）改变不同细胞类型的各种功能，例如内皮细胞，平滑肌细胞，单核细胞，巨噬细胞和T细胞。它与动脉硬化症和炎症性疾病有关。LPC激活许多第二信使，包括蛋白激酶C、细胞外信号调节激酶和蛋白酪氨酸激酶。

General description

溶血磷脂酰胆碱（LPC）是一种在病理反应中分泌的具有生物活性的促炎脂质。它在其极性头部有一个胆碱基团。溶血磷脂酰胆碱（Lyso-PC）是血浆、血管组织和脂蛋白的成分。

Packaging

20 mL透明玻璃螺旋盖小瓶（855475P-500mg）
5 mL棕色玻璃螺旋盖小瓶（855475P-200mg）
5 mL棕色玻璃螺旋盖小瓶（855475P-25mg）

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Inner/outer nuclear membrane fusion in nuclear pore assembly: biochemical demonstration and molecular analysis
Fichtman B, et al.
Molecular Biology of the Cell, 21(23) (2010)
Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor
Ikeno Y, et al.
Test, 280(30) (2005)
Boris Fichtman et al.
Molecular biology of the cell, 21(23), 4197-4211 (2010-10-12)
Nuclear pore complexes (NPCs) are large proteinaceous channels embedded in double nuclear membranes, which carry out nucleocytoplasmic exchange. The mechanism of nuclear pore assembly involves a unique challenge, as it requires creation of a long-lived membrane-lined channel connecting the inner
Shi-Yuan Wen et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 69, 152690-152690 (2018-11-06)
Rhodioloside is a glucoside of tyrosol isolated from Rhodiola rosea. However, its regulating effect on hepatic dyslipidemia of atherogenic mice has rarely been studied. The specific aims of current study included to clarify lipidomic perturbation in liver tissues of apolipoprotein
Yutaka Ikeno et al.
The Journal of biological chemistry, 280(30), 28044-28052 (2005-06-02)
We previously demonstrated that secretory phospholipase A2 (sPLA2) and lysophosphatidylcholine (LPC) exhibit neurotrophin-like neuritogenic activity in the rat pheochromocytoma cell line PC12. In this study, we further analyzed the mechanism whereby sPLA2 displays neurite-inducing activity. Exogenously added mammalian group X
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商品

Critical Micelle Concentrations (CMCs) - Avanti Research™ Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

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