产品名称
C18:1 LPA, 1-(9Z-octadecenyl)-2-hydroxy-sn-glycero-3-phosphate (ammonium salt), powder
方案
>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
表单
powder
包装
pkg of 1 × 1 mg (857230P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 857230P
脂质类型
cardiolipins
phospholipids
运输
dry ice
储存温度
−20°C
SMILES字符串
O[C@](COP([O-])(O)=O)([H])COCCCCCCCC/C=C\CCCCCCCC.[NH4+]
InChI key
WEOSAIXAEGBVPQ-WBIWQBECSA-N
一般描述
C18:1 LPA是一种生物活性脂质。该溶血磷脂酸（LPA）是从膜磷脂中获得的可溶性脂质。它存在于血浆中。
应用
C18:1 LPA适合在萤光素酶测定中刺激人胚胎肾293（HEK 293）细胞。它还适合作为达尔伯克氏改良伊格尔培养基（DMEM）的添加剂，用于跨孔迁移试验、伤口愈合试验和细胞增殖试验。′
生化/生理作用
溶血磷脂酸（LPA）信号转导参与多种细胞过程。它还与神经系统疾病、炎症和癌症有关。
包装
5 mL透明玻璃密封安瓿（857230P-1mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
No data available
闪点(°C)
No data available
Autotaxin is a novel target of micro RNA-101-3p
Wang Y, et al.
FEBS Open Bio, 9(4), 707- 716 (2019)
Lysophosphatidic acid and its receptor LPA1 mediate carrageenan induced inflammatory pain in mice
Srikanth M, et al.
European Journal of Pharmacology, 841, 49- 56 (2018)
R D Moreno-Fernández et al.
Neuropharmacology, 164, 107896-107896 (2019-12-08)
The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the LPA-LPA1-receptor pathway may be involved in mediating the negative consequences
Jesica R Williams et al.
The Journal of biological chemistry, 284(25), 17304-17319 (2009-04-16)
Lysophosphatidic acid (LPA) is a ligand for LPA(1-3) of the endothelial differentiation gene family G-protein-coupled receptors, and LPA(4-8) is related to the purinergic family G-protein-coupled receptor. Because the structure-activity relationship (SAR) of GPR92/LPA(5) is limited and whether LPA is its
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