产品名称
VPC 12249 (S), (S)-phosphoric acid mono-[3-(4-benzyloxy-phenyl)-2-octadec-9-enoylamino-propyl] ester (ammonium salt), powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (857341P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 857341P
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
SMILES string
O=C(CCCCCCC/C=C\CCCCCCCC)N[C@H](COP(O)([O-])=O)CC1=CC=C(OCC2=CC=CC=C2)C=C1.[NH4+]
General description
VPC 12249 is an N-acyl (oleoyl) serine phosphate-based compound.
Application
VPC 12249 has been used as lysophosphatidic acid (LPA)1/3 receptor antagonist in various experimental studies.
Biochem/physiol Actions
Lysophosphatidic acids (LPAs) are bioactive lipid mediators. It interacts with at least six specific LPA receptors (LPA1-6) to mediate extracellular signaling pathway. LPA and its receptors (LPA1-3) are implicated in the pathogenesis of radiation pneumonitis (RP). VPC 12249 (S) inhibits the binding ofLPA to LPA1 and LPA3 receptor.
Packaging
5 mL Amber Glass Screw Cap Vial (857341P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
13 - Non Combustible Solids
wgk
WGK 3