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关于此项目
经验公式（希尔记法）:
C25H29BrN4O2
化学文摘社编号:
分子量:
497.43
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
VU0359595, (1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxamide, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (857371P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 857371P
lipid type
bioactive lipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
Brc1cc2[nH][c]([n](c2cc1)C3CCN(CC3)C[C@@H](NC(=O)[C@H]4[C@@H](C4)c5ccccc5)C)=O
InChI key
JSVNNLRZCJAYTQ-ORYQWCPZSA-N
General description
VU0359595 has been shown to selectively inhibit the PLD1 isoform at nM levels (see data below). **Images added as .gif in folder
Application
VU0359595 has been used as PLD2 (phospholipase D2) inhibitor to quantitatively address functional and molecular aspects of the involvement of PLD-derived phosphatidic acid (PA) in regulated exocytosis and as PLD1 inhibitor to treat the knockout mice to study its effects on them.
Biochem/physiol Actions
VU0359595 helps to block phospholipase D (PLD) which in turn reduces deoxyribonucleoside triphosphate (dNTP) biosynthesis in glioma models.
Packaging
5 mL Amber Glass Screw Cap Vial (857371P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable