产品名称
Brain Sphingosine, D-erythro-Sphingosine (Brain, Porcine), powder
SMILES string
OC[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1
InChI key
WWUZIQQURGPMPG-KRWOKUGFSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (860025P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860025P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
Brain sphingosine is a central metabolite, which is produced from the de novo synthesis of cellular sphingolipids. It is involved in growth, differentiation, survival and cell death. D-erythro-Sphingosine acts as a pharmacological inhibitor of protein kinase C in human platelets. It prevents platelet aggregation in cells.
Application
Brain sphingosine has been used as a standard in the fluorimetric determination of sphingosine in porcine enterocyte monosialogangliosides.
Packaging
5 mL Amber Glass Screw Cap Vial (860025P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
M D Rolsma et al.
Journal of virology, 72(11), 9079-9091 (1998-10-10)
A ganglioside fraction isolated from pooled intestines from newborn to 4-week-old piglets, which we previously partially characterized and showed to specifically inhibit the binding of porcine rotavirus (OSU strain) to host cells (M. D. Rolsma, H. B. Gelberg, and M.
Structure and function of a ganglioside receptor for porcine rotavirus
Rolsma MD, et al.
Journal of Virology, 72(11), 9079-9091 (1998)
Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine
Grimm C, et al.
Molecular Pharmacology, 67(3), 798-805 (2005)
Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets
Khan WA, et al.
The Biochemical Journal, 278(2), 387-392 (1991)
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