产品名称
神经酰胺（脑）, Ceramide (Brain, Porcine), powder
storage temp.
−20°C
SMILES string
N([C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO)C(=O)CCCCCCCCCCCCCCCCC
InChI
1S/C36H71NO3/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-36(40)37-34(33-38)35(39)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h29,31,34-35,38-39H,3-28,30,32-33H2,1-2H3,(H,37,40)/b31-29+/t34-,35+/m0/s1
InChI key
VODZWWMEJITOND-NXCSZAMKSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 200 mg (860052P-200mg)
pkg of 1 × 25 mg (860052P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860052P
lipid type
sphingolipids
shipped in
dry ice
Application
神经酰胺（大脑）可在以下情况下用作脂质标准品
- 在高效液相色谱-电喷雾电离-四极杆飞行时间质谱（UPLC-ESI-Q-TOF-MS）中
- 在配备亲水性相互作用柱的液相色谱中
- 在脂质体制备中测试其对人α-突触核蛋白聚集的影响
Biochem/physiol Actions
神经酰胺是在细胞事件中起关键作用的信号分子。神经酰胺促进β-淀粉样蛋白合成并诱导神经元死亡。神经酰胺水平与许多疾病的发病机制有关。神经酰胺代谢障碍与帕金森病和阿尔茨海默病有关。′′高水平的神经酰胺也与抑郁症有关。
General description
神经酰胺包含通过酰胺键连接到脂肪酰基链的鞘氨醇碱。它们在脂肪酸链和鞘氨醇碱的长度、饱和度和羟基化程度方面各不相同。神经酰胺是鞘磷脂酶通过补救和从头合成途径合成的。在大脑中，神经酰胺合酶介导神经酰胺的合成。
Packaging
5 mL棕色玻璃螺旋盖样品瓶（860052P-200mg）
5 mL棕色玻璃螺旋盖样品瓶（860052P-25mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Astrocytic ceramide as possible indicator of neuroinflammation
de Wit NM, et al.
Journal of Neuroinflammation, 16(1), 48-48 (2019)
James P Madigan et al.
Experimental cell research, 388(2), 111860-111860 (2020-01-24)
There is growing evidence to support a role for the ceramide-metabolizing enzyme, glucosylceramide synthase (GCS), in resistance to a variety of chemotherapeutic agents. Whether GCS contributes to oxaliplatin resistance in colorectal cancer (CRC) has not yet been determined. We have
Ceramide and its related neurochemical networks as targets for some brain disorder therapies
Brodowicz J, et al.
Neurotoxicity Research, 33(2), 474-484 (2018)
Ceramide and Related-Sphingolipid Levels Are Not Altered in Disease-Associated Brain Regions of APPSL and APPSL/PS1M146L Mouse Models of Alzheimer's Disease: Relationship with the Lack of Neurodegeneration?
Barrier L, et al.
International Journal of Alzheimer's Disease, 2011 (2011)
LipidFrag: Improving reliability of in silico fragmentation of lipids and application to the Caenorhabditis elegans lipidome
Witting M, et al.
PLoS ONE, 12(3), e0172311-e0172311 (2017)
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