860063P
Avanti
鞘磷脂
Avanti Research™ - A Croda Brand
别名:
鞘磷脂
描述
Sphingomyelin (Milk, Bovine)
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 200 mg (860063P-200mg)
pkg of 1 × 25 mg (860063P-25mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
脂质类型
sphingolipids
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCC)=O)COP([O-])(OCC[N+](C)(C)C)=O
InChI
1S/C46H93N2O6P/c1-6-8-10-12-14-16-18-20-21-22-23-24-25-26-28-30-32-34-36-38-40-46(50)47-44(43-54-55(51,52)53-42-41-48(3,4)5)45(49)39-37-35-33-31-29-27-19-17-15-13-11-9-7-2/h37,39,44-45,49H,6-36,38,40-43H2,1-5H3,(H-,47,50,51,52)/b39-37+/t44-,45+/m0/s1
InChI key
SXZWBNWTCVLZJN-NMIJJABPSA-N
一般描述
作为细胞膜的主要成分，鞘磷脂在神经细胞（髓鞘）膜和红细胞膜中的浓度特别高。以前认为，它是因鞘氨醇碱基的2-酰胺基、3-羟基和4,5-反式双键介导的分子间相互作用而具有与磷脂酰胆碱功能相似的纯结构作用。但是，现在人们认识到，鞘磷脂对胆固醇具有高亲和力，这两种脂质在液体无序相中紧密堆积成液体有序结构域，形成脂质筏。这些膜微结构域被认为是调节蛋白质定位和相互作用的信号转导平台。但是，鞘磷脂不仅是会影响信号传导的脂质筏成分，它还是神经酰胺和其他鞘脂代谢（包括鞘磷脂循环或鞘脂网络）产物的前体。
鞘磷脂和相关脂质
鞘磷脂和相关脂质
应用
Milk SM 已被用作脂质标准品。它也适用于检测粪便中的神经酰胺和差示扫描量热法。
包装
5 mL棕色玻璃螺旋盖小瓶（860063P-200mg）
5 mL棕色玻璃螺旋盖小瓶（860063P-25mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
S Jyonouchi et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 44(1), 58-68 (2013-10-15)
Eosinophilic esophagitis (EoE) is an atopic disease characterized by eosinophilic inflammation in which dietary antigens (in particular, milk) play a major role. EoE is most likely a mixed IgE and non-IgE food-mediated reaction in which overexpression of Th2 cytokines, particularly
Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids
Kono M, et al.
The Journal of biological chemistry, 281(11), 7324-7331 (2006)
Polymer resonators sensors for detection of sphingolipid gel/fluid phase transition and melting temperature measurement
Li Q, et al.
Sensors and actuators A, Physical, 263, 707-717 (2017)
A relative quantitative positive/negative ion switching method for untargeted lipidomics via high resolution LC-MS/MS from any biological source
Breitkopf S B, et al.
Metabolomics, 13(3), 30-30 (2017)
Mari Kono et al.
The Journal of biological chemistry, 281(11), 7324-7331 (2005-12-29)
Complex sphingolipids are abundant as eukaryotic cell membrane components, whereas their metabolites, in particular ceramide, sphingosine, and sphingosine 1-phosphate, are involved in diverse cell signaling processes. In mammals, degradation of ceramide by ceramidase yields sphingosine, which is phosphorylated by the
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