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文件

860455P

Avanti

N-C12-deoxysphingosine

Name: N-C12-deoxysphingosine
Brand: AVANTI

N-lauroyl-1-deoxysphingosine (m18:1/12:0), powder

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别名:

N-dodecanoyl-1-deoxysphing-4-enine (m18:1/12:0); N-C12-1-deoxyCer; 110992

经验公式（希尔记法）:

C₃₀H₅₉NO₂

CAS号:

1246298-54-3

分子量:

465.79

NACRES:

NA.25

检测方案

>99% (TLC)

形式

powder

包装

pkg of 1 × 1 mg (860455P-1mg)
pkg of 1 × 5 mg (860455P-5mg)

制造商/商品名称

Avanti Polar Lipids 860455P

脂质类型

sphingolipids
bioactive lipids

运输

dry ice

储存温度

−20°C

一般描述

N-C12-deoxysphingosine, also known as 1-deoxydihydroceramide (1-deoxyDHCer) is, the N-acylated form of 1-deoxysphinganine, a potent inhibitor of sphingolipid metabolism.

应用

N-C12-deoxysphingosine has been used as a standard in the quantitation of atypical sphingoid bases in biological samples by reverse-phase liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-MS/MS).

包装

5 mL Amber Glass Screw Cap Vial (860455P-1mg)

5 mL Amber Glass Screw Cap Vial (860455P-5mg)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals.

Nicholas C Zitomer et al.

The Journal of biological chemistry, 284(8), 4786-4795 (2008-12-20)

Fumonisin B(1) (FB(1)) is a mycotoxin that inhibits ceramide synthases (CerS) and causes kidney and liver toxicity and other disease. Inhibition of CerS by FB(1) increases sphinganine (Sa), Sa 1-phosphate, and a previously unidentified metabolite. Analysis of the latter by

Analysis of 1-Deoxysphingoid Bases and Their N-Acyl Metabolites and Exploration of Their Occurrence in Some Food Materials.

Junliang Wan et al.

Journal of agricultural and food chemistry, 67(46), 12953-12961 (2019-10-23)

Most common sphingolipids are comprised of "typical" sphingoid bases (sphinganine, sphingosine, and structurally related compounds) and are produced via the condensation of l-serine with a fatty acyl-CoA by serine palmitoyltransferase. Some organisms, including mammals, also produce "atypical" sphingoid bases that

Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons.

Terina N Martinez et al.

Molecular neurodegeneration, 7, 45-45 (2012-09-15)

Dopaminergic (DA) neurons in the ventral midbrain selectively degenerate in Parkinson's disease (PD) in part because their oxidative environment in the substantia nigra (SN) may render them vulnerable to neuroinflammatory stimuli. Chronic inhibition of soluble Tumor Necrosis Factor (TNF) with

Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols.

Sarah T Pruett et al.

Journal of lipid research, 49(8), 1621-1639 (2008-05-24)

"Sphingosin" was first described by J. L. W. Thudichum in 1884 and structurally characterized as 2S,3R,4E-2-aminooctadec-4-ene-1,3-diol in 1947 by Herb Carter, who also proposed the designation of "lipides derived from sphingosine as sphingolipides." This category of amino alcohols is now

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