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Merck
CN

860474P

Avanti

1-deoxysphinganine-d3

Avanti Research™ - A Croda Brand

别名:

1-deoxysphinganine-d3 (m18:0)

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关于此项目

经验公式（希尔记法）:
C18H36D3NO
化学文摘社编号:
1246298-31-6
分子量:
288.53
MDL number:
MFCD22416649
UNSPSC Code:
12352211
NACRES:
NA.25

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产品名称

1-deoxysphinganine-d3, Avanti Research™ - A Croda Brand 860474P, powder

form

powder

assay

>99% (TLC)

InChI

1S/C18H39NO/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18(20)17(2)19/h17-18,20H,3-16,19H2,1-2H3/t17-,18+/m0/s1/i2D3

InChI key

YRYJJIXWWQLGGV-DRPYBFESSA-N

SMILES string

CCCCCCCCCCCCCCC[C@](O)([H])[C@](N)([H])C([2H])([2H])[2H]

packaging

pkg of 1 × 500 μg (860474P-500ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860474P

shipped in

dry ice

storage temp.

−20°C

Biochem/physiol Actions

1-deoxysphinganine acts as a biomarker for Type 2 diabetes. It can function as a cytotoxic lipid for insulin producing cells. 1-deoxysphinganine might exhibit toxicity to cancerous cells.

General description

1-deoxysphinganine-d3 is a deuterated compound, wherein the three protons of deoxysphinganine are replaced by deuterium. 1-deoxysphinganine is an atypical sphingoid base devoid of a 1-hydroxyl group.

Packaging

5 mL Amber Glass Screw Cap Vial (860474P-500ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

存储类别

11 - Combustible Solids

wgk

WGK 3

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Richard A Zuellig et al.
Diabetes, 63(4), 1326-1339 (2014-01-01)
Irreversible failure of pancreatic β-cells is the main culprit in the pathophysiology of diabetes, a disease that is now a global epidemic. Recently, elevated plasma levels of deoxysphingolipids, including 1-deoxysphinganine, have been identified as a novel biomarker for the disease.
Junliang Wan et al.
Journal of agricultural and food chemistry, 67(46), 12953-12961 (2019-10-23)
Most common sphingolipids are comprised of "typical" sphingoid bases (sphinganine, sphingosine, and structurally related compounds) and are produced via the condensation of l-serine with a fatty acyl-CoA by serine palmitoyltransferase. Some organisms, including mammals, also produce "atypical" sphingoid bases that

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