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经验公式（希尔记法）:
C18H39NO2
化学文摘社编号:
分子量:
301.51
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
Safingol, Avanti Research™ - A Croda Brand 860488P, powder
SMILES string
CCCCCCCCCCCCCCC[C@@](O)([H])[C@@]([H])(N)CO
InChI
1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3
InChI key
OTKJDMGTUTTYMP-UHFFFAOYSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (860488P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860488P
lipid type
sphingolipids
bioactive lipids
shipped in
dry ice
storage temp.
−20°C
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General description
Safingol is a synthetic L-threo-stereoisomer of endogenous (D-erythro-) sphinganine. It acts as an inhibitor of protein kinase C and sphingosine kinase in vitro. Safingol is involved in ceramide generation and induction of apoptosis. It is known to stimulate antitumor activity of cisplatin.
Application
Safingol has been used as a substituent of dihydrosphingosine (dhSph) to increase the cytotoxic response in N-(4-hydroxyphenyl)retinamide (4-HPR)-resistant cells.
Packaging
5 mL Amber Glass Screw Cap Vial (860488P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway
Coward J, et al.
Autophagy, 5(2), 184-193 (2009)
A phase I clinical study of safingol followed by cisplatin: promising activity in refractory adrenocortical cancer with novel pharmacology
Carvajal RD, et al.
Journal of Clinical Oncology, 24(18), 13044-13044 (2006)
Andrej Kováčik et al.
Langmuir : the ACS journal of surfaces and colloids, 34(1), 521-529 (2017-12-13)
Ceramides (Cer) are key components of the skin permeability barrier. Sphingosine-based CerNS and dihydrosphingosine-based CerNdS (dihydroCer) have two chiral centers; however, the importance of the correct stereochemistry in the skin barrier Cer is unknown. We investigated the role of the
Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells
Apraiz A, et al.
BMC Cancer, 11(1), 477-477 (2011)
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